@article {7882,
	title = {Biweekly carboplatin/gemcitabine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: Report of efficacy, quality of life and geriatric assessment},
	journal = {Oncology},
	volume = {73},
	year = {2007},
	note = {Cited By :31Export Date: 21 February 2017},
	month = {2007},
	pages = {290 - 297},
	abstract = {Objective: We evaluated safety and efficacy of first-line gemcitabine/carboplatin in unfit-for-cisplatin patients with advanced urothelial carcinoma and the effect on the quality of life and functional status of elderly patients (aged \&gt;70). Methods: Unfit patients had ECOG performance status (PS) >=2, creatinine clearance \&lt;50 ml/min or comorbidities precluding cisplatin administration. Carboplatin at area under the curve of 2.5 and gemcitabine 1,250 mg/m2 were administered biweekly. Elderly patients were stratified into group 1 (no activities of daily living (ADL) or instrumental ADL dependency and no comorbidities), group 2 (instrumental ADL dependency or 1-2 comorbidities) and group 3 (ADL dependency or >=2 comorbidities). Results: Thirty-four patients were enrolled: 68\% had PS 2-3, 69\% a creatinine clearance \&lt;50 ml/min and 65\% had 1 or more comorbidities. There were 3 cases of grade 3 toxicity (9\%). Response rate was 24\% [95\% confidence interval (CI) 11-41]. Median follow-up was 8 months, median progression-free survival 4.4 months (95\% CI 1.03-7.75) and median overall survival 9.8 months (95\% CI 4.7-14.9). Patients in geriatric assessment groups 1 and 2 had a significantly longer median progression-free survival compared to group 3 [6.9 months (95\% CI 1.3-12.4) vs. 1.9 months (95\% CI 0.5-3.2); p = 0.005]. Conclusion: First-line gemcitabine/carboplatin combination is active in unfit-for-cisplatin patients with advanced urothelial carcinoma. Pretreatment quality of life and geriatric assessment may be useful in selecting patients likely to benefit from this treatment. Copyright {\textcopyright} 2008 S. Karger AG.},
	keywords = {Elderly, Gemcitabine, Unfit, urothelial cancer},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-45549097165\&doi=10.1159\%2f000132394\&partnerID=40\&md5=a28c545bd13e384f9788c99c3e55be76},
	author = {Bamias, A. and Lainakis, G. and Kastritis, E. and Antoniou, N. and Alivizatos, G. and Koureas, A. and Chrisofos, M. and Skolarikos, A. and Karayiotis, E. and Dimopoulos, M.A.}
}
