@article {7897,
	title = {Prognostic and Predictive Factors in Patients with Androgen-Independent Prostate Cancer Treated with Docetaxel and Estramustine: A Single Institution Experience},
	journal = {European Urology},
	volume = {53},
	year = {2008},
	note = {Cited By :18Export Date: 21 February 2017},
	month = {2008},
	pages = {323 - 332},
	abstract = {Objectives: To investigate potential prognostic and predictive factors in patients with androgen-independent prostate cancer (AIPC) treated with docetaxel chemotherapy. Methods: This analysis included 94 consecutive AIPC patients who were treated between March 2001 and May 2006 with biweekly docetaxel 45 mg/m2 (day 2) and estramustine 140 mg three dimes daily (days 1-3). Results: Prostate-specific antigen (PSA) responses were observed in 45 of 84 evaluable patients (53\%), whereas objective responses were observed in 16 of 40 patients with measurable disease (40\%). Median survival (OS) was 16.2 mo (95\% confidence interval [CI], 12.9-19.4) and median time to PSA progression (TTP) 5.0 mo (95\%CI, 3.6-7.1). OS was independently associated with pain score baseline PSA and weight loss. Patients with only extraosseous disease had higher PSA response rate (87\% vs. 49\%, p = 0.014) and superior TTP compared with patients with bone metastases with or without extraosseous disease (7.3 vs. 4.3 vs. 4 mo, p = 0.002). Concurrent bone and extraosseous metastases were associated with worse prognosis compared with each site alone (median OS: 12.3 vs.19 vs.18.3 mo, p = 0.007). Conclusions: Among patients with AIPC treated with biweekly docetaxel and estramustine, baseline PSA \&gt;100, existence of pain, weight loss, and simultaneous extraosseous and bone disease were associated with worse prognosis. Extraosseous metastases seem to be more sensitive than bone disease to this chemotherapy. {\textcopyright} 2007 European Association of Urology.},
	keywords = {Chemotherapy, Docetaxel, Estramustine, Prognosis, Prostate cancer},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37349060061\&doi=10.1016\%2fj.eururo.2007.03.072\&partnerID=40\&md5=0b26b70bbe8e01760b2562c2ac6feb5a},
	author = {Bamias, A. and Bozas, G. and Antoniou, N. and Poulias, I. and Katsifotis, H. and Skolarikos, A. and Mitropoulos, D. and Alamanis, C. and Alivizatos, G. and Deliveliotis, H. and Dimopoulos, M.A.}
}
