@article {7907,
	title = {Two Cycles of Etoposide/Cisplatin Cured All Patients with Stage I Testicular Seminoma: Risk-Adapted Protocol of the Hellenic Cooperative Oncology Group},
	journal = {Urology},
	volume = {70},
	year = {2007},
	note = {Cited By :2Export Date: 21 February 2017},
	month = {2007},
	pages = {1179 - 1183},
	abstract = {Objectives: Adjuvant carboplatin is used as adjuvant therapy in Stage I testicular seminoma. Although cure is the rule, relapses still occur, especially in high-risk populations. We report the results of a risk-adapted strategy by the Hellenic Cooperative Oncology Group. Methods: From 1996 to 2003, 64 patients with Stage I seminoma and one of two risk factors (maximal tumor diameter greater than 4 cm and/or age younger than 34 years) were prospectively included in a protocol of adjuvant chemotherapy. Treatment consisted of two 3-week courses of etoposide 120 mg/m2 and cisplatin 40 mg/m2 for three consecutive days with granulocyte colony-stimulating factor support. Results: Of the 64 patients, 43 (67\%) were younger than 34 years and 55 (86\%) had a tumor diameter greater than 4 cm. Neutropenia and nausea and vomiting were the most frequent grade 3 or 4 toxicities (16.5\% and 9.5\%, respectively), apart from alopecia. After a median follow-up of 60 months (range 7 to 118), no disease relapses have occurred. A metachronous testicular carcinoma has been reported. One patient died of causes unrelated to his disease. Conclusions: The results of our study have shown that two cycles of etoposide and cisplatin is an effective and safe form of adjuvant therapy for Stage I testicular seminoma. Risk factors can be used to identify patients who could benefit from etoposide and cisplatin treatment. {\textcopyright} 2007 Elsevier Inc. All rights reserved.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37349114099\&doi=10.1016\%2fj.urology.2007.07.016\&partnerID=40\&md5=19b2094b40a61bc3586147f7f8c5f1fd},
	author = {Bamias, A. and Aravantinos, G. and Deliveliotis, C. and Thanos, A. and Klouvas, G. and Antoniou, N. and Poulias, I. and Makatsoris, T. and Samantas, E. and Dimopoulos, M.A.}
}
