@article {7931,
	title = {Biweekly gemcitabine and cisplatin in platinum-resistant/refractory, paclitaxel-pretreated, ovarian and peritoneal carcinoma},
	journal = {Gynecologic Oncology},
	volume = {104},
	year = {2007},
	note = {Cited By :19Export Date: 21 February 2017},
	month = {2007},
	pages = {580 - 585},
	abstract = {Objectives: Synergism between gemcitabine and cisplatin is supported by preclinical and clinical data. The present study explores the efficacy of a biweekly regimen in platinum-resistant/refractory, paclitaxel-pretreated ovarian and peritoneal cancer. Methods: 50 paclitaxel-pretreated patients with platinum-resistant/refractory ovarian or peritoneal carcinoma who had previously received paclitaxel chemotherapy, were treated with six cycles of gemcitabine 1000~mg/m2 followed by cisplatin 40~mg/m2 on days 1 and 15, repeated every 4~weeks. Results: The median platinum-free interval (PFI) was 4 months while the median number of previous treatment lines was 2. Chemotherapy was well tolerated. Objective responses were observed in 31.5\% of evaluable patients (n = 35). CA125 response was observed in 68\% of patients with elevated CA125 (n = 41). Median overall survival (OS) was 13.2~months (95\% Confidence Interval, CI: 10.2-16.2) while progression-free survival (PFS) was 4.9 months (95\%CI: 3.5-6.4). A PFI of less than 3 months was associated with lower objective response rates (15.8\% versus 50\%, p = 0.03). Conclusions: Biweekly gemcitabine and cisplatin is feasible for patients with platinum-resistant ovarian or peritoneal cancer and is associated with a favorable toxicity profile. In a population with recent exposure to platinum, a PFI of less than 3~months was the major factor influencing response to chemotherapy. {\textcopyright} 2007 Elsevier Inc. All rights reserved.},
	keywords = {Chemotherapy, Cisplatin, Gemcitabine, Ovarian cancer, refractory, Resistant},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846990923\&doi=10.1016\%2fj.ygyno.2006.09.006\&partnerID=40\&md5=6f8285892eb9bf1b9b03bffdc7f4bbbb},
	author = {Bozas, G. and Bamias, A. and Koutsoukou, V. and Efstathiou, E. and Gika, D. and Papadimitriou, C.A. and Dimopoulos, M.A.}
}
