@article {7936,
	title = {Advanced epithelial ovarian cancer in the elderly: Chemotherapy tolerance and outcome},
	journal = {Anticancer Research},
	volume = {27},
	year = {2007},
	note = {Cited By :10Export Date: 21 February 2017},
	month = {2007},
	pages = {611 - 617},
	abstract = {Background: The prognostic significance of age in ovarian cancer has not been clarified. We investigated the characteristics of ovarian cancer presenting in ages >70 years and assessed the prognostic significance of advanced age. Patients and Methods: Four hundred and fifty-three patients with stage IIC-IV ovarian cancer (age>70 years n=106 [23\%]), treated postoperatively with platinum-based chemotherapy were retrospectively reviewed. Results: Median overall survival (OS) of patients <=70 years old (52.3 months, 95\% CI: 43.2-61.3) was longer than that of older patients (38.8 months, 95\% CI: 29.9-47.7) (p=0.005), but this difference was not significant in a multivariate analysis (p=0.978). Age >70 years was correlated with worse performance status (PS) (p=0.019), higher tumor grade (p=0.033), residual disease >2 cm (p=0.006) and less frequent paclitaxel administration (p<0.001). Toxicity from chemotherapy was similar between the two age groups, but the relative dose intensity of paclitaxel was lower among elderly patients. Conclusion: The worse outcome of ovarian cancer in elderly patients may be attributed to other associated adverse prognostic factors, but advanced age was not an independent prognostic factor.},
	keywords = {Chemotherapy, Elderly, Ovarian cancer, surgery},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847697338\&partnerID=40\&md5=58e08e2952be173f19ae109fe75e42d6},
	author = {Efstathiou, E. and Dimopoulos, M.A. and Bozas, G. and Kastritis, E. and Moulopoulos, L.A. and Rodolakis, A. and Vlahos, G. and Gika, D. and Papadimitriou, C. and Bamias, A.}
}
