@article {7938,
	title = {Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with β-catenin levels and outcome in patients with epithelial ovarian cancer},
	journal = {Annals of Oncology},
	volume = {17},
	year = {2006},
	note = {Cited By :5Export Date: 21 February 2017},
	month = {2006},
	pages = {1797 - 1802},
	abstract = {Background: The deleted in colorectal cancer (DCC) protein, the product of DCC tumor suppressor gene, is frequently altered in cancer. Preclinical data demonstrate that DCC regulates β-catenin levels. Here, we sought to determine the association of DCC with β-catenin protein levels, clinicopathological parameters and patient outcome in ovarian cancer using a method of in situ compartmentalized protein analysis. Methods: A tissue array composed of 150 advanced-stage ovarian cancers, treated with surgical debulking and platinum-paclitaxel (Taxol) combination chemotherapy, was constructed. For evaluation of protein expression, we used an immunofluorescence-based method of automated in situ quantitative measurement of protein analysis (AQUA). Results: One hundred and twelve patients (74\%) had sufficient tissue for AQUA. The median follow-up time for the entire cohort was 33 months. Patients with low nuclear DCC expression had a 3-year progression-free survival (PFS) rate of 0\% compared with 33\% of those with high DCC expression (P = 0.0067). In multivariate analysis, low nuclear DCC expression level retained its prognostic significance for PFS. Between DCC and β-catenin, a significant relationship was found, where tumors with low DCC had low β-catenin and vice versa (P = 0.003). Conclusions: Low nuclear DCC levels predict for poor patient outcome inepithelial ovarian cancer. DCC may exert its antitumor function, in part, through regulation of β-catenin levels. {\textcopyright} 2006 Oxford University Press.},
	keywords = {DCC, Ovarian cancer, Prognosis, β-Catenin},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-33845369401\&doi=10.1093\%2fannonc\%2fmdl310\&partnerID=40\&md5=44c99266b4ca5815ea2eaf7c2a38ff77},
	author = {Bamias, A. and Yu, Z. and Weinberger, P.M. and Markakis, S. and Kowalski, D. and Camp, R.L. and Rimm, D.L. and Dimopoulos, M.A. and Psyrri, A.}
}
