@article {7994,
	title = {Multiple myeloma in elderly patients: Prognostic factors and outcome},
	journal = {European Journal of Haematology},
	volume = {75},
	year = {2005},
	note = {Cited By :34Export Date: 21 February 2017},
	month = {2005},
	pages = {370 - 375},
	abstract = {Objectives: Purpose of this study was to compare prognostic factors and outcome of patients with multiple myeloma (MM) aged > 70 yr at diagnosis with those of younger patients. We also applied the recently proposed International Staging System (ISS) for MM in these patients. Patients and methods: Among 1,162 newly diagnosed, symptomatic MM patients included in our database, 357 (31\%) were > 70 yr of age. Clinical and laboratory variables were evaluated in patients > 70 yr and in younger patients and were assessed for possible correlation with survival in patients > 70 yr of age. Results: Most clinical and laboratory features were similar in the two groups of patients but older patients presented more frequently with advanced ISS (P = 0.02). Despite similar response rates to primary treatment, younger patients survived longer than patients > 70 yr of age (40 vs. 28 months, P = 0.001). There was a longer survival of younger patients than that of older patients diagnosed with ISS stage 1 (median 71 vs. 54 months, P = 0.007) and ISS stage-2 patients (median: 38 vs. 26 months, P = 0.0008) but for patients with ISS stage 3 median survival was similarly poor in the younger and older age group (21 and 20 months, P = 0.283). Other variables associated with impaired prognosis were severe anemia, extensive bone marrow plasmacytosis and elevated serum LDH. Conclusions: Older patients with MM present more often with advanced ISS and have significantly shorter survival than younger patients. The ISS retained its prognostic significance within the group of elderly patients. {\textcopyright} Blackwell Munksgaard 2005.},
	keywords = {age, Elderly, International Staging System, multiple myeloma, Prognostic factors},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-26844556860\&doi=10.1111\%2fj.1600-0609.2005.00532.x\&partnerID=40\&md5=8478e2ae5bc77e53d8175b58eadabbff},
	author = {Anagnostopoulos, A. and Gika, D. and Symeonidis, A. and Zervas, K. and Pouli, A. and Repoussis, P. and Grigoraki, V. and Anagnostopoulos, N. and Economopoulos, T. and Maniatis, A. and Dimopoulos, M.-A.}
}
