@article {8003,
	title = {Gemcitabine plus pegylated liposomal doxorubicin in patients with advanced epithelial ovarian cancer resistant/refractory to platinum and/or taxanes. A HeCOG phase II study},
	journal = {Anticancer Research},
	volume = {25},
	year = {2005},
	note = {Cited By :19Export Date: 21 February 2017},
	month = {2005},
	pages = {3103 - 3108},
	abstract = {Background: A phase II study was conducted to evaluate the efficacy and toxicity of the combination of gemcitabine (GEM) and pegylated liposomal doxorubicin (PLD) in patients with platinum- and/or taxane-resistant/refractory advanced epithelial ovarian cancer (AEOC). Patients and Methods: Patients (pts), who had been treated with platinum or paclitaxel and met the criteria of resistant/refractory AEOC, received GEM 650 mg/m2 days 1 and 8 and PLD 25 mg/m2 day 1 every 4 weeks up to a total of 6 cycles, unless disease progression or adverse effects prohibited further therapy. Results: Thirty-seven patients entered the study. There was 1 complete (3\%) and 7 partial responses (19\%) for an overall response rate of 22\%. Two patients had stable disease (5.5\%). After a median follow-up of 16.2 months, the median survival was 8.4 months and time to treatment failure 2.7 months. The most frequent severe toxicity was myelosuppression recorded in 13 (35\%) patients. Severe stomatitis was recorded in only 2 (5\%) cases and severe palmar-plantar erythrodysesthesia in 1 patient. One severe allergic reaction (grade 4) to PLD was recorded following the third cycle of treatment. Conclusion: The combination of GEM and PLD in patients with AEOC, who are resistant/refractory to platinum and/or Taxanes, did not show any superiority over monotherapy. However, in view of the acceptable toxicity profile, the above combination may deserve further investigation in a randomised setting.},
	keywords = {Gemcitabine, Ovarian cancer, Pegylated liposomal doxorubicin},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-22944470084\&partnerID=40\&md5=30bf7614db5f127140f8e86ec6528d49},
	author = {Skarlos, D.V. and Kalofonos, H.P. and Fountzilas, G. and Dimopoulos, M.A. and N. Pavlidis and Razis, E. and Economopoulos, T. and Pectasides, D. and Gogas, H. and Kosmidis, P. and Bafaloukos, D. and Klouvas, G. and Kyratzis, G. and Aravantinos, G.}
}
