@article {8004,
	title = {Paclitaxel plus carboplatin versus paclitaxel plus alternating carboplatin and cisplatin for initial treatment of advanced ovarian cancer: Long-term efficacy results: A Hellenic Cooperative Oncology Group (HeCOG) study},
	journal = {Annals of Oncology},
	volume = {16},
	year = {2005},
	note = {Cited By :15Export Date: 21 February 2017},
	month = {2005},
	pages = {1116 - 1122},
	abstract = {Background: We compared the combination plus Carboplatin plus paclitaxel, which is considered the treatment of choice for initial chemotherapy of advanced ovarian cancer (AOC) with a regimen combining alternating carboplatin and cisplatin plus paclitaxel. The two platinum derivatives have been previously combined as they are not totally cross-resistant and as they share no overlapping toxicities. Patients and methods: Patients with AOC, after the initial cytoreductive surgery were randomized to either 6 courses of paclitaxel at 175 mg/m2 as 3h infusion plus Carboplatin at 7 AUC (Arm A) or Paclitaxel at the same dose plus Carboplatin again at 7 AUC for cycles 1,3,5, while for cycles 2,4,6 Cisplatin at 75 mg/m2 substituted for Carboplatin (Arm B). Results: 247 patients are analyzed. Significant differences were not found, both in terms of PFS (38 vs 39 months, p=0.95) and overall survival (40.6 vs 38.6 months, p=0.79). There was not also difference in 5-year survival rate (35\% vs 39\%) or 5-year PFS rate (23\% vs 28\%). Age \&gt;60, PS 2, stage IV disease and presence of residual disease were adversely related to the overall survival. Conclusion: Both regimens are well tolerated and effective. Alternating cisplatin with carboplatin does not improve the results compared with the standard combination. {\textcopyright} 2005 European Society fr Medical Oncology.},
	keywords = {Alternating cisplatin with carboplatin, Chemotherapy, Initial treatment, Ovarian cancer},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-25444463805\&doi=10.1093\%2fannonc\%2fmdi223\&partnerID=40\&md5=471ac163bdbf72453dd85fa767d3eb71},
	author = {Aravantinos, G. and Fountzilas, G. and Kosmidis, P. and Dimopoulos, M.A. and Stathopoulos, G. P. and N. Pavlidis and Bafaloukos, D. and Papadimitriou, C. and Karpathios, S. and Georgoulias, V. and Papakostas, P. and Kalofonos, H.P. and Grimani, E. and Skarlos, D.V.}
}
