@article {8008,
	title = {Bcl-2 protein and DNA ploidy in renal cell carcinoma: Do they affect patient prognosis?},
	journal = {International Journal of Urology},
	volume = {12},
	year = {2005},
	note = {Cited By :5Export Date: 21 February 2017},
	month = {2005},
	pages = {563 - 569},
	abstract = {Aim: The aim of the present study was to correlate bcl-2 protein expression and DNA-ploidy status with established prognostic parameters in renal cell carcinoma (RCC) and to examine their impact on disease progression and patient survival. Methods: Both parameters were prospectively measured in 50 consecutive radical nephrectomy specimens using flow cytometry. They were correlated with the tumor grade, stage and histological type. Kaplan-Meier survival analysis for all parameters was performed. Results: Bcl-2 protein expression was higher in RCC compared to normal renal tissue (P < 0.0001). Aneuploid tumors had higher bcl-2 expression compared to diploid tumors (P = 0.015). Bcl-2 expression and DNA content were not correlated with tumor histological types (P = 0.277/ P = 0.419), grades (P = 0.690/P = 0.449), T categories (P = 0.637/P = 0.585) or stages (P = 0.726/ P = 0.800). Median follow-up time was 46 months (range, 5-84) with a mean overall survival of 61.8 months (95\% confidence interval, 53.7-69.9). Tumor stage was the only statistically important prognostic factor (P = 0.0045). Conclusion: Although Bcl-2 expression was correlated with tumor DNA content, the prognostic value of these two parameters following radical nephrectomy was not established.},
	keywords = {Bcl-2, DNA ploidy, Prognosis, Renal cell carcinoma},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-23244448002\&doi=10.1111\%2fj.1442-2042.2005.01081.x\&partnerID=40\&md5=9a458d3914cc558976306d14f699891c},
	author = {Skolarikos, A. and Alivizatos, G. and Bamias, A. and Mitropoulos, D. and Ferakis, N. and Deliveliotis, C. and Dimopoulos, M.-A.}
}
