@article {8013,
	title = {Carboplatin hypersensitivity reactions: A single institution experience},
	journal = {Journal of Chemotherapy},
	volume = {17},
	year = {2005},
	note = {Cited By :11Export Date: 21 February 2017},
	month = {2005},
	pages = {104 - 110},
	abstract = {Carboplatin-related hypersensitivity reactions, frequently encountered in the heavily pretreated subpopulation of patients with gynecologic malignancies, can be severe and even potentially lethal - precluding these patients from an effective salvage treatment. We describe our experience in the management of such reactions and the application of a pretreatment protocol with corticosteroids, antihistamines and a slow infusion rate in order to safely re-administer carboplatin to the above patients. From 1998 to 2004, twenty patients developed an allergic reaction to carboplatin. Sixteen of them (80\%) suffered from ovarian cancer. Upon resolution of the acute reaction, thirteen patients were pretreated according to our protocol and were re-exposed to carboplatin. Fifteen patients experienced the reaction during second-line carboplatin-based treatment and 5 patients after 3 or more regimens. Fifteen of the reactions (75\%) were severe. Thirteen patients were re-treated with carboplatin after the application of our protocol, all of them successfully, even though 10 patients (77\%) experienced minor symptoms during subsequent courses. On the contrary, only one of the 6 patients who were re-treated without the application of the protocol was able to receive further platinum-based treatment. In conclusion, pretreatment with corticosteroids, antihistamines and a slower infusion rate may make re-treatment possible in patients having experienced hypersensitivity to carboplatin. {\textcopyright} E.S.I.F.T. srl - Firenze.},
	keywords = {Carboplatin, Hypersensitivity, Ovarian cancer},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-16244367765\&partnerID=40\&md5=20c4175b90b08e64af6b85a4c3bfc445},
	author = {Zorzou, M.P. and Efstathiou, E. and Galani, E. and Bozas, G. and Kastritis, E. and Papadimitriou, C. and Dimopoulos, M.A. and Bamias, A.}
}
