@article {8014,
	title = {The outcome of elderly patients with advanced urothelial carcinoma after platinum-based combination chemotherapy},
	journal = {Annals of Oncology},
	volume = {16},
	year = {2005},
	note = {Cited By :44Export Date: 21 February 2017},
	month = {2005},
	pages = {307 - 313},
	abstract = {Background: The majority of patients with advanced urothelial cancer are elderly, but data regarding this specific age group are limited. We compared the tolerability and efficacy of first-line platinum (cisplatin or carboplatin)-based chemotherapy in elderly patients (>=70 years) with those in younger patients. Patients and methods: A total of 381 patients with advanced urothelial carcinoma received CIMV (cisplatin, ifosphamide, methotrexate, vinblastine) (n=32), MVAC (methotrexate, vinblastine, doxorubicin, cisplatin) (n=105), DC (docetaxel, cisplatin) (n=174), CaG (carboplatin, gemcitabine) (n=64) or other regimes (n=6) and were included in this analysis. Results: A total of 116 patients were >=70 years. Elderly patients experienced more frequent neutropenia grade 3/4 (55\% versus 37\%, P=0.087) and renal toxicity (28\% versus 10\%, P=0.033) among patients treated with CIMV/MVAC, and neutropenic infections (4\% versus 0\%, P=0.019) among patients treated with DC. Median survival did not differ significantly between elderly and younger patients (9.3 versus 10.5 months, P=0.16). Eastern Cooperative Oncology Group performance status (PS) and haemoglobin were independently associated with prognosis. Patients with PS <2 and haemoglobin >=10g/dl had a median survival of 14 months as opposed to 5 months for patients with PS >=2 or haemoglobin <10g/dl (P <0.001). Conclusion: Elderly patients with advanced urothelial cancer tolerate platinum-based chemotherapy well and derive the same benefit as their younger counterparts. {\textcopyright} 2005 European Society for Medical Oncology.},
	keywords = {Bladder cancer, Chemotherapy, Elderly, Platinum},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-20044373437\&doi=10.1093\%2fannonc\%2fmdi039\&partnerID=40\&md5=a2ae28933dc2c515cc0afaf17a15dc7e},
	author = {Bamias, A. and Efstathiou, E. and Moulopoulos, L.A. and Gika, D. and Hamilos, G. and Zorzou, M.P. and Kakoyiannis, C. and Kastritis, E. and Bozas, G. and Papadimitriou, C. and Dimopoulos, M.A.}
}
