@article {8069,
	title = {2-Chlorodeoxyadenosine alone and in combination for previously untreated Waldenstrom{\textquoteright}s macroglobulinemia},
	journal = {Seminars in Oncology},
	volume = {30},
	year = {2003},
	note = {Cited By :88Export Date: 21 February 2017},
	month = {2003},
	pages = {243 - 247},
	abstract = {Treatment for Waldenstrom{\textquoteright}s macroglobulinemia (WM) has usually been reserved for symptomatic patients and has included alkylating agent-steroid combinations and, more recently, nucleoside analogues. We now describe our experience with 2-chlorodeoxyadenosine (2-CdA) alone and in combination at our center. We treated 90 consecutive, previously untreated patients with symptomatic WM using either 2-CdA alone or in combination with other agents including prednisone (pred), cyclophosphamide (Cy), and rituximab (Rit) as follows: January 1991 to December 1992 - 2-CdA 0.1 mg/kg by continuous infusion (CI) over 24 hours for days (16 patients); December 1992 to December 1995 - 2-CdA 0.1 mg/kg CI over 24 hours for 7 days plus pred 60 mg/m2 orally daily for 7 days (20 patients); July 1996 to March 1998 - 2-CdA 1.5 mg/m2 by subcutaneous injection (SC) every 8 hours for 7 days plus Cy 40 mg/m2 orally twice daily for 7 days (37 patients); August 1999 to December 2001 - 2-CdA 1.5 mg/m2 SC every 8 hours for 7 days plus Cy 40 mg/m2 orally twice daily for 7 days plus Rit 375 mg/m2 by intravenous infusion (IV) weekly for 4 weeks (17 patients). For nearly all patients, a second course was repeated after at least 6 weeks. Responding patients were monitored without further treatment until relapse. Overall response (complete [CR] + partial response [PR]) was 94\% for 2-CdA alone, 60\% for 2-CdA/pred, 84\% for 2-CdA/Cy, and 94\% for 2-CdA/Cy/Rit. Median overall survival is 73 months for 2-CdA, 41 months for 2-CdA/pred, and has not been reached for 2-CdA/Cy or 2-CdA/Cy/Rit. Cause-specific survival for 2-CdA/pred is 78 months and has not been reached for all other programs. The only poor prognostic factor for cause-specific survival was hemoglobin \&lt; 9 g/dL. 2-CdA regimens provide excellent response rates and improve cause-specific survival, with minimal treatment and little toxicity. These observations support the potential role of 2-CdA regimens as the treatment of choice for previously untreated WM. {\textcopyright} 2003 Elsevier Inc. All rights reserved.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037396195\&doi=10.1053\%2fsonc.2003.50070\&partnerID=40\&md5=cbf89adc74ed9fd4850d2d96f49b4197},
	author = {Weber, D.M. and Dimopoulos, M.A. and Delasalle, K. and Rankin, K. and Gavino, M. and Alexanian, R.}
}
