@article {8075,
	title = {Detection of malignant bone marrow involvement with dynamic contrast-enhanced magnetic resonance imaging},
	journal = {Annals of Oncology},
	volume = {14},
	year = {2003},
	note = {Cited By :40Export Date: 21 February 2017},
	month = {2003},
	pages = {152 - 158},
	abstract = {Background: The purpose of this study was to evaluate the role of dynamic contrast-enhanced magnetic resonance imaging (dMRI) in detecting bone marrow involvement in cancer patients. Patients and methods: We studied 50 consecutive patients with histologically confirmed malignant dissemination to the bone marrow, using dMRI of the lumbosacral spine. Time-signal intensity curves were generated from regions of interest (ROIs) obtained from areas of obvious bone marrow disease (group B). In 16 patients from group B with focal disease, ROIs were also placed on areas with apparently normal bone marrow on static magnetic resonance images (group C). Twenty-two patients with no history of malignancy were used as a control group (group A). Wash-in (WIN) and wash-out (WOUT) rates, time to peak (TTPK), time to maximum slope (TMSP) values and WIN/TMSP ratios were calculated for each patient. Mean values for the three groups were compared statistically. Six patients from group B had follow-up dMRI after chemotherapy: four patients achieved a clinical partial response and two had resistant disease. Results: A significant difference was found between groups A and B for all values. Between groups A and C, in spite of the similar static MRI appearance, all values were significantly different. Between groups B and C, a significant difference was found for WIN, WOUT rates and WIN/TMSP ratio. Follow-up dMRI data analysis correlated well with clinical staging. Conclusions: dMRI can distinguish normal from malignant bone marrow. It may identify malignant bone marrow infiltration in patients with negative static MRI and serve as both a diagnostic and prognostic tool for patients with bone marrow malignancies.},
	keywords = {bone marrow, Dynamic magnetic resonance imaging, Magnetic Resonance Imaging},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-12244297397\&doi=10.1093\%2fannonc\%2fmdg007\&partnerID=40\&md5=8b7287ce2bd9c82dcc3b2af0b5500297},
	author = {Moulopoulos, L.A. and Maris, T.G. and N. Papanikolaou and Panagi, G. and Vlahos, L. and Dimopoulos, M.A.}
}
