@article {8180,
	title = {Testicular lymphoma: Late relapses and poor outcome despite doxorubicin-based therapy},
	journal = {Journal of Clinical Oncology},
	volume = {13},
	year = {1995},
	note = {Cited By :95Export Date: 21 February 2017},
	month = {1995},
	pages = {1361 - 1367},
	abstract = {Purpose: To determine the significance of the International Prognostic Index (IPI) score in adults with testicular lymphoma treated with doxorubicin-based regimens. Patients and Methods: Untreated adults with testicular lymphoma who presented between 1969 and 1993 were studied. Those with Ann Arbor stages III and IV were included if they had a testicular mass at presentation. Results: We identified 22 patients, 21 with intermediate-grade and one with high-grade lymphoma. All 10 patients with an IPI score <= 1 had Ann Arbor stage I disease, whereas the 12 with an IPI score more than 1 had Ann Arbor stage II to IV disease. Complete remission (CR) was achieved in 73\% of patients. At 153 months, 22\% of all complete responders and 40\% and 0\% of those with IPI scores <= 1 and more than 1, respectively, remained in CR (P = .01). With a median follow-up time of 113 months for survivors, the failure-free survival (FFS) rate at 153 months was 16\% for all patients or 32\% and 0\% for those with IPI scores <= 1 and more than 1, respectively (P = .02). The CNS or contralateral testis were involved in all patients who failed to respond to primary therapy and in 50\% of those who relapsed from CR. Conclusion: The prognosis of patients with testicular lymphoma appears poor despite doxorubicin-based chemotherapy. On the basis of failures in the CNS and contralateral testis, we recommend prophylactic intrathecal chemotherapy and scrotal radiotherapy for all patients. Those with an IPI score <= 1 can be treated with conventional doxorubicin-based regimens, but those with an IPI score more than 1 should be considered for investigational systemic therapy. {\textcopyright} 1995 by American Society of Clinical Oncology.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029060546\&partnerID=40\&md5=4b364562e333026dcc5427d76cadf9d3},
	author = {Touroutoglou, N. and Dimopoulos, M.A. and Younes, A. and Hess, M. and Pugh, W. and Cox, J. and Cabanillas, F. and A.H. Sarris}
}
