@article {8192,
	title = {Pharmacokinetics, dosimetry and toxicity of holmium-166-DOTMP for bone marrow ablation in multiple myeloma},
	journal = {Journal of Nuclear Medicine},
	volume = {36},
	year = {1995},
	note = {Cited By :64Export Date: 21 February 2017},
	month = {1995},
	pages = {730 - 737},
	abstract = {In this Phase I clinical trial, six multiple myeloma patients who had not responded to conventional therapy and were scheduled for bone marrow transplantation received a bone-seeking radiopharmaceutical for bone marrow ablation. The pharmacokinetics, dosimetry, and toxicity of this radiopharmaceutical were studied. Methods: Patients received from 519 mCi to 2.1 Ci (19.2 GBq to 77.7 GBq) of holmium-166 (166Ho) complexed with a bone-seeking agent, DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10- tetramethylene-phosphonic acid). The reproducibility of pharmacokinetics from multiple injections of 166Ho-DOTMP administered to these myeloma patients was demonstrated from blood (r2 = 0.926) and whole-body retention (r2 = 0.983), which allowed therapeutic parameters to be determined from a diagnostic study. Results: Over 50\% of the 166Ho-DOTMP injected dose was excreted within 2-3 hr postinjection, increasing to 75\%-85\% over a 24-hr period. Rapid blood clearance minimized radiation dose to nontarget tissue: less than 10\% of the injected activity was retained in the blood pool at 1 hr postinjection, and less than 2\% remained after 5 hr. The total radiation absorbed dose delivered to the bone marrow for the six patients ranged from 7.9 Gy to 41.4 Gy. Conclusion: All patients demonstrated severe bone marrow toxicity with a white blood cell (WBC) count \&lt; 1,000 cells/μl, two patients exhibited marrow ablation (WBC count \&lt; 100 cells/μl), and no other toxicity >=grade 2 was observed in any of the patients.},
	keywords = {marrow ablation, marrow dosimetry, radionuclide therapy},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029012120\&partnerID=40\&md5=c5446a17ca05d5f632ccb30e514be89e},
	author = {Bayouth, J.E. and Macey, D.J. and Kasi, L.P. and Garlich, J.R. and McMillan, K. and Dimopoulos, M.A. and Champlin, R.E.}
}
