@article {8256,
	title = {Effects of furosemide on pulmonary shunts},
	journal = {Chest},
	volume = {96},
	year = {1989},
	note = {Cited By :7Export Date: 21 February 2017},
	month = {1989},
	pages = {494 - 498},
	abstract = {In 23 mechanically ventilated anuric (six) or oliguric (17) patients (\&lt; 16 ml/h of urine output) with severe gas exchange abnormality, we investigated the effect of furosemide on intrapulmonary shunt (Q̇S/Q̇T). Before and after 0.5, 1, and 2 h of IV administration of 200 mg of furosemide, we assessed the intrapulmonary shunt and PaO2 while patients{\textquoteright} hemodynamic measurements were monitored. Ventilatory parameters remained constant throughout the study. While the urine output was minimal and no alteration in hemodynamic values was found, the Q̇S/Q̇T decreased from 27.7 {\textpm} 2.3 percent (mean {\textpm} SEM) at control to 24.3 {\textpm} 2.1 percent (p \&lt; 0.01) at 0.5 h, 21.7 {\textpm} 2.1 percent (P \&lt; 0.001) at 1 h, and 18.1 {\textpm} 1.8 percent (p \&lt; 0.001) at 2 h. The PaO2 showed no significant difference at 0.5 h but rose significantly from 96 {\textpm} 14 to 105 {\textpm} 14 mm Hg (p \&lt; 0.05) and 111 {\textpm} 14 mm Hg (p \&lt; 0.01) at 1 and 2 h, respectively. Since we observed no changes in hemodynamics, we speculate a direct effect of furosemide in the pulmonary vasculature affecting the ventilation-perfusion mismatch and, therefore, the Q̇S/Q̇T and PaO2.},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024445289\&partnerID=40\&md5=2b5569c48ebeb4d9576bc903afda8a89},
	author = {Baltopoulos, G. and Zakynthinos, S. and Dimopoulos, A. and Roussos, C.}
}
