<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>13</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chng, W.-J.</style></author><author><style face="normal" font="default" size="100%">Goldschmidt, H.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Moreau, P.</style></author><author><style face="normal" font="default" size="100%">Joshua, D.</style></author><author><style face="normal" font="default" size="100%">Palumbo, A.</style></author><author><style face="normal" font="default" size="100%">Facon, T.</style></author><author><style face="normal" font="default" size="100%">Ludwig, H.</style></author><author><style face="normal" font="default" size="100%">Pour, L.</style></author><author><style face="normal" font="default" size="100%">Niesvizky, R.</style></author><author><style face="normal" font="default" size="100%">Oriol, A.</style></author><author><style face="normal" font="default" size="100%">Rosiñol, L.</style></author><author><style face="normal" font="default" size="100%">Suvorov, A.</style></author><author><style face="normal" font="default" size="100%">Gaidano, G.</style></author><author><style face="normal" font="default" size="100%">Pika, T.</style></author><author><style face="normal" font="default" size="100%">Weisel, K.</style></author><author><style face="normal" font="default" size="100%">Goranova-Marinova, V.</style></author><author><style face="normal" font="default" size="100%">Gillenwater, H.H.</style></author><author><style face="normal" font="default" size="100%">Mohamed, N.</style></author><author><style face="normal" font="default" size="100%">Feng, S.</style></author><author><style face="normal" font="default" size="100%">Aggarwal, S.</style></author><author><style face="normal" font="default" size="100%">Hájek, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Carfilzomib–dexamethasone vs bortezomib–dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR</style></title><secondary-title><style face="normal" font="default" size="100%">Leukemia</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011631341&amp;doi=10.1038%2fleu.2016.390&amp;partnerID=40&amp;md5=11667e9c85f2255bfce2ff0a1fc1399b</style></url></web-urls></urls><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The randomized phase 3 study ENDEAVOR demonstrated a statistically significant and clinically meaningful improvement in progression-free survival (PFS) for carfilzomib and dexamethasone (Kd) vs bortezomib and dexamethasone (Vd) in relapsed or refractory multiple myeloma (MM). We conducted a preplanned subgroup analysis of ENDEAVOR to evaluate Kd vs Vd by cytogenetic risk. Of 785 patients with known cytogenetics, 210 (27%) had high-risk cytogenetics (Kd, n=97 (25%); Vd, n=113 (28%)) and 575 (73%) had standard-risk cytogenetics (Kd, n=284 (75%); Vd, n=291 (72%)). Median PFS in the high-risk group was 8.8 months for Kd vs 6.0 months for Vd (hazard ratio (HR), 0.65; 95% confidence interval (CI), 0.45–0.92; P=0.0075). Median PFS in the standard-risk group was not estimable for Kd vs 10.2 months for Vd (HR, 0.44; 95% CI, 0.33–0.58; P&lt;0.0001). Overall response rates were 72.2% (Kd) vs 58.4% (Vd) in the high-risk group and 79.2% (Kd) vs 66.0% (Vd) in the standard-risk group. In the high-risk group, 15.5% (Kd) vs 4.4% (Vd) achieved a complete response (CR) or better. In the standard-risk group, 13.0% (Kd) vs 7.9% (Vd) achieved ⩾CR. This preplanned subgroup analysis found that Kd was superior to Vd in relapsed or refractory MM, regardless of cytogenetic risk.Leukemia advance online publication, 3 February 2017; doi:10.1038/leu.2016.390. © 2017 The Author(s)</style></abstract><notes><style face="normal" font="default" size="100%">Export Date: 18 February 2017Article in Press</style></notes></record></records></xml>