<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>13</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ziogas, D.C.</style></author><author><style face="normal" font="default" size="100%">Kastritis, E.</style></author><author><style face="normal" font="default" size="100%">Terpos, E.</style></author><author><style face="normal" font="default" size="100%">Roussou, M.</style></author><author><style face="normal" font="default" size="100%">Migkou, M.</style></author><author><style face="normal" font="default" size="100%">Gavriatopoulou, M.</style></author><author><style face="normal" font="default" size="100%">Spanomichou, D.</style></author><author><style face="normal" font="default" size="100%">Eleutherakis-Papaiakovou, E.</style></author><author><style face="normal" font="default" size="100%">Fotiou, D.</style></author><author><style face="normal" font="default" size="100%">Panagiotidis, I.</style></author><author><style face="normal" font="default" size="100%">Kafantari, E.</style></author><author><style face="normal" font="default" size="100%">Psimenou, E.</style></author><author><style face="normal" font="default" size="100%">Boletis, I.</style></author><author><style face="normal" font="default" size="100%">Vlahakos, D.V.</style></author><author><style face="normal" font="default" size="100%">Gakiopoulou, H</style></author><author><style face="normal" font="default" size="100%">Matsouka, C.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hematologic and renal improvement of monoclonal immunoglobulin deposition disease after treatment with bortezomib-based regimens</style></title><secondary-title><style face="normal" font="default" size="100%">Leukemia and Lymphoma</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">bortezomib</style></keyword><keyword><style  face="normal" font="default" size="100%">ESRD</style></keyword><keyword><style  face="normal" font="default" size="100%">MIDD</style></keyword><keyword><style  face="normal" font="default" size="100%">proteinuria</style></keyword><keyword><style  face="normal" font="default" size="100%">renal response</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2016</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006132730&amp;doi=10.1080%2f10428194.2016.1267349&amp;partnerID=40&amp;md5=71d7ffe1b458a1fc513a1098e233e3b9</style></url></web-urls></urls><pages><style face="normal" font="default" size="100%">1 - 8</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Monoclonal immunoglobulin deposition disease (MIDD) is characterized by non-organized immunoglobulin-fragments along renal basement membranes with subsequent organ deterioration. Treatment is directed against the immunoglobulin-producing clone. We treated 18 MIDD patients with bortezomib-based regimens (12 received bortezomib-dexamethasone, 6 bortezomib-dexamethasone with cyclophosphamide). Eleven (61%) patients achieved a hematologic response, but only 6 (33.3%) reached to a complete (CR) or very good partial response (VGPR). Regarding renal outcomes 77.8 and 55.6% had ≥30 and ≥50% reduction of proteinuria, respectively, but 33.3% ended up in end-stage renal disease (ESRD). Among patients with CR or VGPR, median eGFR improvement was 7.7 ml/min/1.73 m2 and none progressed to ESRD, but no significant renal recovery was observed in patients achieving a partial response or less, with 50% progressing to dialysis. Pretreatment eGFR seems to influence renal prognosis. Bortezomib-based treatment is considered an effective approach in MIDD and reaching to a deep hematologic response (≥VGPR) conditionally controls further renal declining. © 2016 Informa UK Limited, trading as Taylor &amp; Francis Group</style></abstract><notes><style face="normal" font="default" size="100%">Export Date: 21 February 2017Article in Press</style></notes></record></records></xml>