<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Orlowski, R.Z.</style></author><author><style face="normal" font="default" size="100%">Gercheva, L.</style></author><author><style face="normal" font="default" size="100%">Williams, C.</style></author><author><style face="normal" font="default" size="100%">Sutherland, H.</style></author><author><style face="normal" font="default" size="100%">Robak, T.</style></author><author><style face="normal" font="default" size="100%">Masszi, T.</style></author><author><style face="normal" font="default" size="100%">Goranova-Marinova, V.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Cavenagh, J.D.</style></author><author><style face="normal" font="default" size="100%">Špička, I.</style></author><author><style face="normal" font="default" size="100%">Maiolino, A.</style></author><author><style face="normal" font="default" size="100%">Suvorov, A.</style></author><author><style face="normal" font="default" size="100%">Bladé, J.</style></author><author><style face="normal" font="default" size="100%">Samoylova, O.</style></author><author><style face="normal" font="default" size="100%">Puchalski, T.A.</style></author><author><style face="normal" font="default" size="100%">Reddy, M.</style></author><author><style face="normal" font="default" size="100%">Bandekar, R.</style></author><author><style face="normal" font="default" size="100%">van de Velde, H.</style></author><author><style face="normal" font="default" size="100%">Xie, H.</style></author><author><style face="normal" font="default" size="100%">Rossi, J.-F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma</style></title><secondary-title><style face="normal" font="default" size="100%">American Journal of Hematology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919683208&amp;doi=10.1002%2fajh.23868&amp;partnerID=40&amp;md5=179d1a29102aeacb41c6374beee528dc</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">90</style></volume><pages><style face="normal" font="default" size="100%">42 - 49</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">We compared the safety and efficacy of siltuximab (S), an anti-interleukin-6 chimeric monoclonal antibody, plus bortezomib (B) with placebo (plc) + B in patients with relapsed/refractory multiple myeloma in a randomized phase 2 study. Siltuximab was given by 6 mg/kg IV every 2 weeks. On progression, B was discontinued and high-dose dexamethasone could be added to S/plc. Response and progression-free survival (PFS) were analyzed pre-dexamethasone by European Group for Blood and Marrow Transplantation (EBMT) criteria. For the 281 randomized patients, median PFS for S + B and plc + B was 8.0 and 7.6 months (HR 0.869, P = 0.345), overall response rate was 55 versus 47% (P = 0.213), complete response rate was 11 versus 7%, and median overall survival (OS) was 30.8 versus 36.8 months (HR 1.353, P = 0.103). Sustained suppression of C-reactive protein, a marker reflective of inhibition of interleukin-6 activity, was seen with S + B. Siltuximab did not affect B pharmacokinetics. Siltuximab/placebo discontinuation (75 versus 66%), grade ≥3 neutropenia (49 versus 29%), thrombocytopenia (48 versus 34%), and all-grade infections (62 versus 49%) occurred more frequently with S + B. The addition of siltuximab to bortezomib did not appear to improve PFS or OS despite a numerical increase in response rate in patients with relapsed or refractory multiple myeloma. © 2014 Wiley Periodicals, Inc.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><notes><style face="normal" font="default" size="100%">Cited By :31Export Date: 21 February 2017</style></notes></record></records></xml>