<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Weise, K.C.</style></author><author><style face="normal" font="default" size="100%">Song, K.W.</style></author><author><style face="normal" font="default" size="100%">Delforge, M.</style></author><author><style face="normal" font="default" size="100%">Karlin, L.</style></author><author><style face="normal" font="default" size="100%">Goldschmidt, H.</style></author><author><style face="normal" font="default" size="100%">Moreau, P.</style></author><author><style face="normal" font="default" size="100%">Banos, A.</style></author><author><style face="normal" font="default" size="100%">Oriol, A.</style></author><author><style face="normal" font="default" size="100%">Garderet, L.</style></author><author><style face="normal" font="default" size="100%">Cavo, M.</style></author><author><style face="normal" font="default" size="100%">Ivanova, V.</style></author><author><style face="normal" font="default" size="100%">Alegre, A.</style></author><author><style face="normal" font="default" size="100%">Martinez-Lopez, J.</style></author><author><style face="normal" font="default" size="100%">Chen, C.</style></author><author><style face="normal" font="default" size="100%">Spencer, A.</style></author><author><style face="normal" font="default" size="100%">Knop, S.</style></author><author><style face="normal" font="default" size="100%">Bahlis, N.J.</style></author><author><style face="normal" font="default" size="100%">Renner, C.</style></author><author><style face="normal" font="default" size="100%">Yu, X.</style></author><author><style face="normal" font="default" size="100%">Hong, K.</style></author><author><style face="normal" font="default" size="100%">Sternas, L.</style></author><author><style face="normal" font="default" size="100%">Jacques, C.</style></author><author><style face="normal" font="default" size="100%">Zaki, M.H.</style></author><author><style face="normal" font="default" size="100%">San Miguel, J.F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone</style></title><secondary-title><style face="normal" font="default" size="100%">Haematologica</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943235889&amp;doi=10.3324%2fhaematol.2014.117077&amp;partnerID=40&amp;md5=021647f725584917124705d6b5026281</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">100</style></volume><pages><style face="normal" font="default" size="100%">1327 - 1333</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall survival benefits from treatment with pomalidomide plus low-dose dexamethasone compared to high-dose dexamethasone among patients in whom bortezomib and lenalidomide treatment had failed. At an updated median follow-up of 15.4 months, the progression-free survival was 4.0 versus 1.9 months (HR, 0.50; P&lt;0.001), and median overall survival was 13.1 versus 8.1 months (HR, 0.72; P=0.009). Pomalidomide plus low-dose dexamethasone, compared with highdose dexamethasone, improved progression-free survival in patients with del(17p) (4.6 versus 1.1 months; HR, 0.34; P &lt;0.001), t(4;14) (2.8 versus 1.9 months; HR, 0.49; P=0.028), and in standard-risk patients (4.2 versus 2.3 months; HR, 0.55; P&lt;0.001). Although the majority of patients treated with high-dose dexamethasone took pomalidomide after discontinuation, the overall survival of patients treated with pomalidomide plus low-dose dexamethasone or highdose dexamethasone was 12.6 versus 7.7 months (HR, 0.45; P=0.008) in patients with del(17p), 7.5 versus 4.9 months (HR, 1.12; P=0.761) in those with t(4;14), and 14.0 versus 9.0 months (HR, 0.85; P=0.380) in standard-risk subjects. The overall response rate was higher in patients treated with pomalidomide plus low-dose dexamethasone than in those treated with high-dose dexamethasone both among standard-risk patients (35.2% versus 9.7%) and those with del(17p) (31.8% versus 4.3%), whereas it was similar in patients with t(4;14) (15.9% versus 13.3%). The safety of pomalidomide plus low-dose dexamethasone was consistent with initial reports. In conclusion, pomalidomide plus low-dose dexamethasone is efficacious in patients with relapsed/refractory multiple myeloma and del(17p) and/or t(4;14). This study is registered at ClinicalTrials.gov as NCT01311687 and with EudraCT as 2010-019820-30. © 2015 Ferrata Storti Foundation.</style></abstract><issue><style face="normal" font="default" size="100%">10</style></issue><notes><style face="normal" font="default" size="100%">Cited By :12Export Date: 21 February 2017</style></notes></record></records></xml>