<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Petrucci, M.T.</style></author><author><style face="normal" font="default" size="100%">Giraldo, P.</style></author><author><style face="normal" font="default" size="100%">Corradini, P.</style></author><author><style face="normal" font="default" size="100%">Teixeira, A.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Blau, I.W.</style></author><author><style face="normal" font="default" size="100%">Drach, J.</style></author><author><style face="normal" font="default" size="100%">Angermund, R.</style></author><author><style face="normal" font="default" size="100%">Allietta, N.</style></author><author><style face="normal" font="default" size="100%">Broer, E.</style></author><author><style face="normal" font="default" size="100%">Mitchell, V.</style></author><author><style face="normal" font="default" size="100%">Bladé, J.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A prospective, international phase 2 study of bortezomib retreatment in patients with relapsed multiple myeloma</style></title><secondary-title><style face="normal" font="default" size="100%">British Journal of Haematology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">bortezomib</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple myeloma</style></keyword><keyword><style  face="normal" font="default" size="100%">Phase 2</style></keyword><keyword><style  face="normal" font="default" size="100%">relapsed</style></keyword><keyword><style  face="normal" font="default" size="100%">Retreatment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2013</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873990173&amp;doi=10.1111%2fbjh.12198&amp;partnerID=40&amp;md5=ca52bc357fbd746a99d3186f2195c23d</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">160</style></volume><pages><style face="normal" font="default" size="100%">649 - 659</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Multiple myeloma (MM) typically follows a relapsing course with many patients requiring multiple therapies. This single-arm phase 2 study prospectively evaluated the efficacy and safety of bortezomib retreatment in MM patients who had relapsed after achieving at least a partial response (≥PR) to prior bortezomib-based therapy. Patients aged ≥18years, with measurable, secretory MM, who relapsed ≥6months after prior bortezomib treatment were eligible. Patients received up to eight cycles of bortezomib (±dexamethasone). The primary endpoint was best confirmed response at retreatment; secondary endpoints included duration of response (DOR), time to progression (TTP), and safety. Adverse events (AEs) were graded by National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. A total of 130 patients (median of two prior lines of therapy) were enrolled and received retreatment. At retreatment, 28% and 72% of patients received bortezomib and bortezomib-dexamethasone, respectively. Overall response rate was 40%. In patients who achieved ≥PR, median DOR and TTP were 6·5 and 8·4months, respectively. Thrombocytopenia was the most common grade ≥3 AE (35%). Forty percent of patients experienced neuropathy events, which improved and resolved in a median of 1·5 and 8·9months, respectively. In conclusion, bortezomib retreatment was effective and tolerable in relapsed MM patients, with no evidence of cumulative toxicities. © 2013 Blackwell Publishing Ltd.</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><notes><style face="normal" font="default" size="100%">Cited By :54Export Date: 21 February 2017</style></notes></record></records></xml>