<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Colombo, N.</style></author><author><style face="normal" font="default" size="100%">Kutarska, E.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.</style></author><author><style face="normal" font="default" size="100%">Bae, D.-S.</style></author><author><style face="normal" font="default" size="100%">Rzepka-Gorska, I.</style></author><author><style face="normal" font="default" size="100%">Bidzinski, M.</style></author><author><style face="normal" font="default" size="100%">Scambia, G.</style></author><author><style face="normal" font="default" size="100%">Engelholm, S.A.</style></author><author><style face="normal" font="default" size="100%">Joly, F.</style></author><author><style face="normal" font="default" size="100%">Weber, D.</style></author><author><style face="normal" font="default" size="100%">El-Hashimy, M.</style></author><author><style face="normal" font="default" size="100%">Li, J.</style></author><author><style face="normal" font="default" size="100%">Souami, F.</style></author><author><style face="normal" font="default" size="100%">Wing, P.</style></author><author><style face="normal" font="default" size="100%">Engelholm, S.</style></author><author><style face="normal" font="default" size="100%">Bamias, A.</style></author><author><style face="normal" font="default" size="100%">Schwartz, P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Randomized, open-label, phase III study comparing patupilone (EPO906) with pegylated liposomal doxorubicin in platinum-refractory or -resistant patients with recurrent epithelial ovarian, primary fallopian tube, or primary peritoneal cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Clinical Oncology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2012</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-84869109927&amp;doi=10.1200%2fJCO.2011.38.8082&amp;partnerID=40&amp;md5=1daaa19302c4a3022cbf182a6553bcd7</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">30</style></volume><pages><style face="normal" font="default" size="100%">3841 - 3847</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Purpose: This study compared the efficacy and safety of patupilone with those of pegylated liposomal doxorubicin (PLD) in patients with platinum-refractory or -resistant epithelial ovarian, primary fallopian tube, or primary peritoneal cancer. Patients and Methods: Patients with three or fewer prior regimens were eligible if they had received first-line taxane/ platinum-based combination chemotherapy and were platinum refractory or resistant. Patients were randomly assigned to receive patupilone (10 mg/m 2 intravenously every 3 weeks) or PLD (50 mg/m2 intravenously every 4 weeks). Results: A total of 829 patients were randomly assigned (patupilone, n = 412; PLD, n = 417). There was no statistically significant difference in overall survival (OS), the primary end point, between the patupilone and PLD arms (P = .195; hazard ratio, 0.93; 95% CI, 0.79 to 1.09), with median OS rates of 13.2 and 12.7 months, respectively. Median progression-free survival was 3.7 months for both arms. The overall response rate (all partial responses) was higher in the patupilone arm than in the PLD arm (15.5% v 7.9%; odds ratio, 2.11; 95% CI, 1.36 to 3.29), although disease control rates were similar (59.5% v 56.3%, respectively). Frequently observed adverse events (AEs) of any grade included diarrhea (85.3%) and peripheral neuropathy (39.3%) in the patupilone arm and mucositis/stomatitis (43%) and hand-foot syndrome (41.8%) in the PLD arm. Conclusion: Patupilone did not demonstrate significant improvement in OS compared with the active control, PLD. No new or unexpected serious AEs were identified. © 2012 by American Society of Clinical Oncology.</style></abstract><issue><style face="normal" font="default" size="100%">31</style></issue><notes><style face="normal" font="default" size="100%">Cited By :50Export Date: 21 February 2017</style></notes></record></records></xml>