<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Hussein, M.</style></author><author><style face="normal" font="default" size="100%">Swern, A.S.</style></author><author><style face="normal" font="default" size="100%">Weber, D.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of lenalidomide dose on progression-free survival in patients with relapsed or refractory multiple myeloma</style></title><secondary-title><style face="normal" font="default" size="100%">Leukemia</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dexamethasone</style></keyword><keyword><style  face="normal" font="default" size="100%">Lenalidomide</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple myeloma</style></keyword><keyword><style  face="normal" font="default" size="100%">progression-free survival</style></keyword><keyword><style  face="normal" font="default" size="100%">refractory</style></keyword><keyword><style  face="normal" font="default" size="100%">relapsed</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054028441&amp;doi=10.1038%2fleu.2011.126&amp;partnerID=40&amp;md5=2abcb129829b982e606a69d5b8fc443f</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">25</style></volume><pages><style face="normal" font="default" size="100%">1620 - 1626</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">This analysis assessed the effect of lenalidomide on progression-free survival (PFS). Patients with relapsed or refractory multiple myeloma (RRMM) who received lenalidomide plus dexamethasone in the MM-009 and MM-010 trials were pooled and those who had not progressed and were still receiving lenalidomide at 12 months were included. The median follow-up of surviving patients was 48 months. Of 353 patients who received lenalidomide plus dexamethasone, 116 (33%) had not progressed. Overall, 52 patients (45%) had no dose reductions, 25 (22%) had dose reductions ≥12 months and 39 (34%) had dose reductions before 12 months. Patients who had dose reductions ≥12 months had a significantly longer median PFS than those who had reductions before 12 months (P=0.007) or no dose reductions (P=0.039) (not reached vs 28.0 vs 36.8 months, respectively). In a multivariate Cox regression model, dose reduction ≥12 months was an independent predictor of improved PFS (hazard ratio, 0.47; 95% confidence interval, 0.23-0.98) after adjusting for patient characteristics. The data suggest that to achieve maximum PFS benefit, patients with RRMM should be treated for ≥12 months with full-dose lenalidomide plus dexamethasone. Thereafter, patients may benefit from lower-dose continued therapy; prospective studies are needed to confirm these findings. © 2011 Macmillan Publishers Limited All rights reserved.</style></abstract><issue><style face="normal" font="default" size="100%">10</style></issue><notes><style face="normal" font="default" size="100%">Cited By :13Export Date: 21 February 2017</style></notes></record></records></xml>