<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fountzilas, G.</style></author><author><style face="normal" font="default" size="100%">Kourea, H.P.</style></author><author><style face="normal" font="default" size="100%">Bobos, M.</style></author><author><style face="normal" font="default" size="100%">Televantou, D.</style></author><author><style face="normal" font="default" size="100%">Kotoula, V.</style></author><author><style face="normal" font="default" size="100%">Papadimitriou, C.</style></author><author><style face="normal" font="default" size="100%">Papazisis, K.T.</style></author><author><style face="normal" font="default" size="100%">Timotheadou, E.</style></author><author><style face="normal" font="default" size="100%">Efstratiou, I.</style></author><author><style face="normal" font="default" size="100%">Koutras, A.</style></author><author><style face="normal" font="default" size="100%">Pentheroudakis, G.</style></author><author><style face="normal" font="default" size="100%">Christodoulou, C.</style></author><author><style face="normal" font="default" size="100%">Aravantinos, G.</style></author><author><style face="normal" font="default" size="100%">Miliaras, D.</style></author><author><style face="normal" font="default" size="100%">Petraki, K.</style></author><author><style face="normal" font="default" size="100%">Papandreou, C.N.</style></author><author><style face="normal" font="default" size="100%">Papakostas, P.</style></author><author><style face="normal" font="default" size="100%">Bafaloukos, D.</style></author><author><style face="normal" font="default" size="100%">Repana, D.</style></author><author><style face="normal" font="default" size="100%">Razis, E.</style></author><author><style face="normal" font="default" size="100%">Pectasides, D.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, A.M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Paclitaxel and bevacizumab as first line combined treatment in patients with metastatic breast cancer: The Hellenic Cooperative Oncology Group experience with biological marker evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bevacizumab</style></keyword><keyword><style  face="normal" font="default" size="100%">breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Paclitaxel</style></keyword><keyword><style  face="normal" font="default" size="100%">Vascular endothelial growth factor receptors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-80051626503&amp;partnerID=40&amp;md5=5c71d5f7b2a46518a67fbac0b390281e</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">31</style></volume><pages><style face="normal" font="default" size="100%">3007 - 3018</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Background: Randomized studies have shown that bevacizumab combined with taxane-based regimens increases response rates and prolongs progression-free survival (PFS) of patients with metastatic breast cancer (MBC). However predictive or prognostic biological markers that identify the appropriate target population, thus improving the cost-effectiveness ratio of this treatment, are still needed. Patients and Methods: Retrospectively, 124 patients with MBC treated either with paclitaxel 90 mg/m2 weekly x12 plus bevacizumab 10 μg/kg every 2 weeks or 15 μg/kg every 3 weeks (85 patients) or paclitaxel 175 mg/m2 plus bevacizumab 15 μg/kg every 3 weeks for 6 cycles (36 patients) were identified. Additionally, the prognostic significance of a panel of key biological markers was evaluated centrally by immunohistochemistry (IHC) in 88 evaluable patients. Results: More than two thirds of the patients completed chemotherapy, as planned. The response rate was almost identical (55.3% vs. 55.6%) in the patients treated with weekly or 3-weekly paclitaxel, respectively. After a median follow-up time of 23 months, the median PFS of the study population was 13 months, while median survival had not yet been reached. Common severe adverse events were neutropenia (33%), neuropathy (18.6%) and metabolic disturbances (17.6%). The incidence of hypertension of all grades was 28.1%. High expression of vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) was associated with clinical response, while high expression of VEGFR1 was associated with poor survival. Conclusion: The safety and activity of the combination of bevacizumab with paclitaxel given either weekly or 3-weekly in patients with MBC is confirmed.</style></abstract><issue><style face="normal" font="default" size="100%">9</style></issue><notes><style face="normal" font="default" size="100%">Cited By :20Export Date: 21 February 2017</style></notes></record></records></xml>