<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bournakis, E.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Bamias, A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Management of advanced bladder cancer in patients with impaired renal function</style></title><secondary-title><style face="normal" font="default" size="100%">Expert Review of Anticancer Therapy</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">advanced bladder cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">cisplatin ineligible</style></keyword><keyword><style  face="normal" font="default" size="100%">impaired renal failure</style></keyword><keyword><style  face="normal" font="default" size="100%">platinum based</style></keyword><keyword><style  face="normal" font="default" size="100%">platinum free</style></keyword><keyword><style  face="normal" font="default" size="100%">transitional cell carcinoma</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-79959773808&amp;doi=10.1586%2fera.10.197&amp;partnerID=40&amp;md5=bc4ed3d67f6f34e4e6cb6b06c756b67e</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">931 - 939</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Advanced transitional-cell carcinoma of the bladder is the most common cancer of the urinary tract, with a high mortality rate. Cisplatin-based chemotherapy has demonstrated prolonged survival of these patients and is considered the standard of care. Nevertheless, 40-50% of patients have impaired renal function that precludes the use of cisplatin. The non-nephrotoxic platinum analogue, carboplatin, has emerged as the most popular alternative in this setting, used mainly in doublets. However, it has not shown similar efficacy to cisplatin. In this article, platinum-based or platinum-free regimens, monotherapies or combination therapies are discussed as treatment options for this population. Their efficacy and toxicity are also being analyzed. The study of newer targeted therapies in the treatment of bladder cancer is also discussed, as are future perspectives and a five-year view in the treatment of the disease in patients with renal impairment. © 2011 Expert Reviews Ltd.</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><notes><style face="normal" font="default" size="100%">Cited By :6Export Date: 21 February 2017</style></notes></record></records></xml>