<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Delforge, M.</style></author><author><style face="normal" font="default" size="100%">Terpos, E.</style></author><author><style face="normal" font="default" size="100%">Richardson, P.G.</style></author><author><style face="normal" font="default" size="100%">Shpilberg, O.</style></author><author><style face="normal" font="default" size="100%">Khuageva, N.K.</style></author><author><style face="normal" font="default" size="100%">Schlag, R.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Kropff, M.</style></author><author><style face="normal" font="default" size="100%">Spicka, I.</style></author><author><style face="normal" font="default" size="100%">Petrucci, M.T.</style></author><author><style face="normal" font="default" size="100%">Samoilova, O.S.</style></author><author><style face="normal" font="default" size="100%">Mateos, M.-V.</style></author><author><style face="normal" font="default" size="100%">Magen-Nativ, H.</style></author><author><style face="normal" font="default" size="100%">Goldschmidt, H.</style></author><author><style face="normal" font="default" size="100%">Esseltine, D.-L.</style></author><author><style face="normal" font="default" size="100%">Ricci, D.S.</style></author><author><style face="normal" font="default" size="100%">Liu, K.</style></author><author><style face="normal" font="default" size="100%">Deraedt, W.</style></author><author><style face="normal" font="default" size="100%">Cakana, A.</style></author><author><style face="normal" font="default" size="100%">van de Velde, H.</style></author><author><style face="normal" font="default" size="100%">San Miguel, J.F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. Melphalan-prednisone in the phase III VISTA trial in multiple myeloma</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Haematology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bone</style></keyword><keyword><style  face="normal" font="default" size="100%">bortezomib</style></keyword><keyword><style  face="normal" font="default" size="100%">Melphalan-prednisone</style></keyword><keyword><style  face="normal" font="default" size="100%">myeloma</style></keyword><keyword><style  face="normal" font="default" size="100%">VISTA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-79954426340&amp;doi=10.1111%2fj.1600-0609.2011.01599.x&amp;partnerID=40&amp;md5=a79e91d9a5784d9d6f17ba50423f417b</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">86</style></volume><pages><style face="normal" font="default" size="100%">372 - 384</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Objectives: Bone disease is a key presenting feature of myeloma. This post hoc analysis of the phase III VISTA trial of bortezomib plus melphalan-prednisone (VMP) vs. MP in previously untreated myeloma patients assessed clinical bone disease events and changes in alkaline phosphatase (ALP), a marker for osteoblast activation, and serum Dickkopf-1 (DKK-1), an inhibitor of osteoblast differentiation, during treatment. Methods: Patients received nine 6-wk cycles of VMP (bortezomib 1.3mg/m 2, days 1, 4, 8, 11, 22, 25, 29, 32, cycles 1-4, days 1, 8, 22, 29, cycles 5-9, plus melphalan 9mg/m 2 and prednisone 60mg/m 2, days 1-4, cycles 1-9; N=344) or MP alone (N=338). Results: Rates of bisphosphonates use during treatment (73% vs. 82%), progression because of worsening bone disease (3% vs. 11%), and requirement for subsequent radiotherapy (3% vs. 8%) were lower with VMP vs. MP. Median maximum ALP increase was significantly higher with VMP vs. MP overall (49.7% vs. 30.3%, P=0.029), and higher by response group (complete response [CR]: 68.7% vs. 43.9%; partial response [PR]: 41.5% vs. 31.2%). Greater maximum ALP increase was strongly associated with achievement of CR (P≤0.0001) and CR/PR (P≤0.01). Median DKK-1 decreased with VMP by 694.4pg/mL and increased with MP by 1273.3pg/mL from baseline to day 4 (P=0.0069). Available radiologic data revealed evidence of bone healing in 6/11 VMP-treated patients, who achieved best responses of three CR, one PR, and two stable disease. Conclusions: These results suggest a positive effect of bortezomib on bone metabolism and potentially bone healing in myeloma. © 2011 John Wiley and Sons A/S.</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><notes><style face="normal" font="default" size="100%">Cited By :42Export Date: 21 February 2017</style></notes></record></records></xml>