<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Richardson, P.G.</style></author><author><style face="normal" font="default" size="100%">Schlag, R.</style></author><author><style face="normal" font="default" size="100%">Khuageva, N.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.</style></author><author><style face="normal" font="default" size="100%">Shpilberg, O.</style></author><author><style face="normal" font="default" size="100%">Kropff, M.</style></author><author><style face="normal" font="default" size="100%">Vekemans, M.-C.</style></author><author><style face="normal" font="default" size="100%">Petrucci, M.T.</style></author><author><style face="normal" font="default" size="100%">Rossiev, V.</style></author><author><style face="normal" font="default" size="100%">Hou, J.</style></author><author><style face="normal" font="default" size="100%">Robak, T.</style></author><author><style face="normal" font="default" size="100%">Mateos, M.-V.</style></author><author><style face="normal" font="default" size="100%">Anderson, K.</style></author><author><style face="normal" font="default" size="100%">Esseltine, D.-L.</style></author><author><style face="normal" font="default" size="100%">Cakana, A.</style></author><author><style face="normal" font="default" size="100%">Liu, K.</style></author><author><style face="normal" font="default" size="100%">Deraedt, W.</style></author><author><style face="normal" font="default" size="100%">van de Velde, H.</style></author><author><style face="normal" font="default" size="100%">San Miguel, J.F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterization of haematological parameters with bortezomib-melphalan-prednisone versus melphalan-prednisone in newly diagnosed myeloma, with evaluation of long-term outcomes and risk of thromboembolic events with use of erythropoiesis-stimulating agent</style></title><secondary-title><style face="normal" font="default" size="100%">British Journal of Haematology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">bortezomib</style></keyword><keyword><style  face="normal" font="default" size="100%">Erythropoiesis-stimulating agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Melphalan</style></keyword><keyword><style  face="normal" font="default" size="100%">myeloma</style></keyword><keyword><style  face="normal" font="default" size="100%">Prednisone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953088636&amp;doi=10.1111%2fj.1365-2141.2011.08569.x&amp;partnerID=40&amp;md5=90241429ab6b2cca52f901c67832e129</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">153</style></volume><pages><style face="normal" font="default" size="100%">212 - 221</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Although haematological toxicities, such as anaemia, are common in multiple myeloma (MM), no clear consensus exists on the use and impact of erythropoiesis-stimulating agents (ESA) on outcomes in MM. This analysis characterizes haematological toxicities and associated interventions in the phase III VISTA (Velcade ® as Initial Standard Therapy in Multiple Myeloma: Assessment with Melphalan and Prednisone) study of bortezomib plus melphalan/prednisone (VMP, n=344) versus MP (n=338) in previously untreated MM patients ineligible for high-dose therapy, and evaluates the impact of ESA use or red-blood-cell (RBC) transfusions on outcomes and thromboembolic risk. Incidence of haematological toxicities was similar with VMP and MP; similar rates of interventions and associated complications (e.g. bleeding, febrile neutropenia) were observed. Two hundred thirty three patients received ESA; 204 had RBC transfusions. Frequency of thromboembolic events was low and not affected by ESA use. Median time-to progression (TTP) was similar between ESA/non-ESA [hazard ratio: 1·03 (95% confidence interval 0·76-1·39); P=0·8478] in both arms (VMP: 19·9/not reached; MP: 15·0/17·5months). Three-year overall survival (OS) rates were similar between ESA/non-ESA in each arm. Patients receiving RBC transfusions had significantly shorter OS (P&amp;lt;0·0001) versus non-RBC-transfusion patients. In conclusion, bortezomib did not add to melphalan haematological toxicity. Concomitant ESA use with VMP/MP in previously untreated MM patients did not adversely affect TTP or OS, or increase thromboembolic risk. However, RBC transfusion was associated with significantly shorter survival. © 2011 Blackwell Publishing Ltd.</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><notes><style face="normal" font="default" size="100%">Cited By :4Export Date: 21 February 2017</style></notes></record></records></xml>