<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Grass, S.</style></author><author><style face="normal" font="default" size="100%">Preuss, K.-D.</style></author><author><style face="normal" font="default" size="100%">Wikowicz, A.</style></author><author><style face="normal" font="default" size="100%">Terpos, E.</style></author><author><style face="normal" font="default" size="100%">Ziepert, M.</style></author><author><style face="normal" font="default" size="100%">Nikolaus, D.</style></author><author><style face="normal" font="default" size="100%">Yang, Y.</style></author><author><style face="normal" font="default" size="100%">Fadle, N.</style></author><author><style face="normal" font="default" size="100%">Regitz, E.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Treon, S.P.</style></author><author><style face="normal" font="default" size="100%">Hunter, Z.R.</style></author><author><style face="normal" font="default" size="100%">Pfreundschuh, M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hyperphosphorylated paratarg-7: A new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenström macroglobulinemia</style></title><secondary-title><style face="normal" font="default" size="100%">Blood</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953105788&amp;doi=10.1182%2fblood-2010-09-306076&amp;partnerID=40&amp;md5=9887d449814f8150db7c287ab1f8bb26</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">117</style></volume><pages><style face="normal" font="default" size="100%">2918 - 2923</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">We recently described paratarg-7 (P-7), a protein of unknown function, as the target of 15% of immunoglobulin A (IgA) and IgG paraproteins in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma. To determine the frequency of P-7 as a paraprotein target in IgM-MGUS and Waldenström macroglobulinemia (WM), sera from patients with IgM-MGUS/WM were tested for reactivity with recombinant P-7 by enzyme-linked immunoabsorbent assay. The specificity of the paraprotein-mediated reaction was shown by absorption studies and cloning of the respective B-cell receptor. The paraproteins of 18 (9 WM and 9 IgM-MGUS) of 161 patients (11%) reacted with P-7. Isoelectric focusing and phosphatase treatment showed that P-7 was hyperphosphorylated (pP-7) in all patients with an anti - P-7-specific IgM paraprotein tested. Because only 4 of 200 healthy controls (2%) were carriers of pP-7, pP-7 carrier state is associated with a significantly increased risk (odds ratio = 6.2; P = .001) for developing IgM-MGUS/MW. Family analyses showed that the pP-7 carrier state is inherited as a dominant trait. After IgA/IgGMGUS and multiple myeloma, IgMMGUS/WM is the second neoplasia associated with pP-7 carrier state. The dominant inheritance of pP-7 explains cases of familial IgM-MGUS/WM and enables the identification of family members at increased risk. © 2011 by The American Society of Hematology.</style></abstract><issue><style face="normal" font="default" size="100%">10</style></issue><notes><style face="normal" font="default" size="100%">Cited By :17Export Date: 21 February 2017</style></notes></record></records></xml>