<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Mateos, M.-V.</style></author><author><style face="normal" font="default" size="100%">Richardson, P.G.</style></author><author><style face="normal" font="default" size="100%">Schlag, R.</style></author><author><style face="normal" font="default" size="100%">Khuageva, N.K.</style></author><author><style face="normal" font="default" size="100%">Shpilberg, O.</style></author><author><style face="normal" font="default" size="100%">Kropff, M.</style></author><author><style face="normal" font="default" size="100%">Spicka, I.</style></author><author><style face="normal" font="default" size="100%">Palumbo, A.</style></author><author><style face="normal" font="default" size="100%">Wu, K.L.</style></author><author><style face="normal" font="default" size="100%">Esseltine, D.-L.</style></author><author><style face="normal" font="default" size="100%">Liu, K.</style></author><author><style face="normal" font="default" size="100%">Deraedt, W.</style></author><author><style face="normal" font="default" size="100%">Cakana, A.</style></author><author><style face="normal" font="default" size="100%">van de Velde, H.</style></author><author><style face="normal" font="default" size="100%">San Miguel, J.F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk factors for, and reversibility of, peripheral neuropathy associated with bortezomib-melphalan-prednisone in newly diagnosed patients with multiple myeloma: Subanalysis of the phase 3 VISTA study</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Haematology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">bortezomib</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple myeloma</style></keyword><keyword><style  face="normal" font="default" size="100%">peripheral neuropathy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phase 3</style></keyword><keyword><style  face="normal" font="default" size="100%">Subanalysis</style></keyword><keyword><style  face="normal" font="default" size="100%">VISTA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-78650110658&amp;doi=10.1111%2fj.1600-0609.2010.01533.x&amp;partnerID=40&amp;md5=09bbfbbf2f1d5155e0de1dcfefd39471</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">86</style></volume><pages><style face="normal" font="default" size="100%">23 - 31</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Objectives: This subanalysis of the phase 3 VISTA trial aimed to assess the frequency, characteristics and reversibility of, and prognostic factors for, bortezomib-associated peripheral neuropathy (PN) in newly diagnosed patients with multiple myeloma ineligible for high-dose therapy who received bortezomib plus melphalan-prednisone.Methods: Patients received nine 6-wk cycles of VMP (bortezomib 1.3 mg/m2, days 1, 4, 8, 11, 22, 25, 29, 32, cycles 1-4, and days 1, 8, 22, 29, cycles 5-9; melphalan 9 mg/m2, days 1-4, cycles 1-9; and prednisone 60 mg/m2, days 1-4, cycles 1-9).Results: Overall, 47% of patients receiving VMP developed PN, including 19% grade 2 and 13% grade ≥3 (&amp;lt;1% grade 4). The PN incidence was dose-related and reached a plateau at a cumulative bortezomib dose of approximately 45 mg/m2. Median time to PN onset was 2.3 months. Bortezomib-associated PN was reversible; 79% of events improved by at least one NCI CTCAE grade within a median of 1.9 months and 60% completely resolved within a median of 5.7 months, with reversibility similar in responding and non-responding patients. By multivariate analysis, baseline neuropathy was the only consistent risk factor for any PN [hazard ratio (HR) 1.785, P = 0.0065], grade ≥2 PN (HR 2.205, P = 0.0032), and grade ≥3 PN (HR 2.438, P = 0.023); age, pre-existing diabetes, International Staging System stage, obesity, and creatinine clearance did not affect the overall rate of PN.Conclusions: Rates of bortezomib-induced PN in the frontline setting were similar to those in relapsed patients and resolved in most cases. (Clinicaltrials.gov identifier: NCT00111319). © 2010 John Wiley &amp;amp; Sons A/S.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><notes><style face="normal" font="default" size="100%">Cited By :50Export Date: 21 February 2017</style></notes></record></records></xml>