<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Papadimitriou, C.A.</style></author><author><style face="normal" font="default" size="100%">Kalofonos, H.</style></author><author><style face="normal" font="default" size="100%">Zagouri, F.</style></author><author><style face="normal" font="default" size="100%">Papakostas, P.</style></author><author><style face="normal" font="default" size="100%">Bozas, G.</style></author><author><style face="normal" font="default" size="100%">Makatsoris, T.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.-A.</style></author><author><style face="normal" font="default" size="100%">Fountzilas, G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Weekly docetaxel with or without gemcitabine as second-line chemotherapy in paclitaxel-pretreated patients with metastatic breast cancer: A randomized phase II study conducted by the hellenic co-operative oncology group</style></title><secondary-title><style face="normal" font="default" size="100%">Oncology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Docetaxel</style></keyword><keyword><style  face="normal" font="default" size="100%">Gemcitabine</style></keyword><keyword><style  face="normal" font="default" size="100%">Metastatic breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Second-line chemotherapy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2009</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-69549087942&amp;doi=10.1159%2f000236021&amp;partnerID=40&amp;md5=4dab1a442243e2e107d6cbf1d8c04c4d</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">77</style></volume><pages><style face="normal" font="default" size="100%">212 - 216</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Objective: A randomized phase II trial was conducted to test whether the addition of gemcitabine to weekly docetaxel could improve the objective response rate and survival outcomes as second-line chemotherapy in patients with metastatic breast cancer who have failed a paclitaxel-containing regimen. Methods: Patients were randomized to receive either weekly docetaxel 40 mg/m2 (group A, n = 34) or the combination of weekly docetaxel 35 mg/m2 with gemcitabine 600 mg/m2 (group B, n = 41). Three consecutive weekly infusions followed by a 1-week rest period represented 1 chemotherapy cycle. Results: The objective response rate was 18% and 27.5% in group A and B, respectively (p = 0.413). No statistically significant differences were demonstrated in terms of median overall survival and time to disease progression. The rate and grade 3 and 4 neutropenia were higher in group B (23 vs. 3%). Conclusions: The weekly administration of docetaxel and gemcitabine did not result in superior clinical outcomes over weekly docetaxel. © 2009 S. Karger AG, Basel.</style></abstract><issue><style face="normal" font="default" size="100%">3-4</style></issue><notes><style face="normal" font="default" size="100%">Cited By :6Export Date: 21 February 2017</style></notes></record></records></xml>