<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Economopoulos, T.</style></author><author><style face="normal" font="default" size="100%">Psyrri, A.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Kalogera-Fountzila, A.</style></author><author><style face="normal" font="default" size="100%">N. Pavlidis</style></author><author><style face="normal" font="default" size="100%">Tsatalas, C.</style></author><author><style face="normal" font="default" size="100%">Nikolaides, C.</style></author><author><style face="normal" font="default" size="100%">Mellou, S.</style></author><author><style face="normal" font="default" size="100%">Xiros, N.</style></author><author><style face="normal" font="default" size="100%">Fountzilas, G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">CEOP-21 versus CEOP-14 chemotherapy with or without rituximab for the first-line treatment of patients with aggressive lymphomas: Results of the HE22A99 trial of the hellenic cooperative oncology group</style></title><secondary-title><style face="normal" font="default" size="100%">Cancer Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aggressive non-Hodgkin lymphoma</style></keyword><keyword><style  face="normal" font="default" size="100%">CEOP</style></keyword><keyword><style  face="normal" font="default" size="100%">Doseintensification</style></keyword><keyword><style  face="normal" font="default" size="100%">Overall survival</style></keyword><keyword><style  face="normal" font="default" size="100%">rituximab</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2007</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-38449114046&amp;doi=10.1097%2fPPO.0b013e3181570170&amp;partnerID=40&amp;md5=b586a2bb82538d08b0675ea05974ac3c</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">327 - 334</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Background: In this study we investigated whether administering CEOP (cyclophosphamide, epirubicin, vincristine [Oncovin], and prednisone) every 2 weeks (CEOP-14) instead of every 3 weeks (the standard CEOP-21 regimen) improves outcomes in patients with previously untreated aggressive lymphomas. In a secondary analysis we evaluated the impact of adding rituximab to CEOP-14/CEOP-21 chemotherapy. Study Design: The trial opened in March 1999, and patients were randomly assigned to either CEOP-14 or CEOP-21. All patients enrolled from May 2002 onward received rituximab with each chemotherapy cycle, and those attaining a complete response received rituximab consolidation. Results: Complete and overall response rates in the CEOP-21 ± rituximab (N ≤ 114) and CEOP-14 ± rituximab (N ≤ 103) arms were similar, as were the overall survival (P ≤ 0.769) and time to progression distributions (P ≤ 0.969). Rituximab was shown to have a beneficial effect both on the overall survival and on the time to progression. Conclusions: Thus far, no significant improvement in outcome has been demonstrated with CEOP-14 ± rituximab versus CEOP-21 ± rituximab. However, with addition of rituximab to CEOP-21/CEOP-14, significant improvements in time to progression and overall survival were achieved. © 2007 by Lippincott Williams &amp; Wilkins.</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><notes><style face="normal" font="default" size="100%">Cited By :9Export Date: 21 February 2017</style></notes></record></records></xml>