<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anagnostopoulos, A.</style></author><author><style face="normal" font="default" size="100%">Gika, D.</style></author><author><style face="normal" font="default" size="100%">Symeonidis, A.</style></author><author><style face="normal" font="default" size="100%">Zervas, K.</style></author><author><style face="normal" font="default" size="100%">Pouli, A.</style></author><author><style face="normal" font="default" size="100%">Repoussis, P.</style></author><author><style face="normal" font="default" size="100%">Grigoraki, V.</style></author><author><style face="normal" font="default" size="100%">Anagnostopoulos, N.</style></author><author><style face="normal" font="default" size="100%">Economopoulos, T.</style></author><author><style face="normal" font="default" size="100%">Maniatis, A.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.-A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Multiple myeloma in elderly patients: Prognostic factors and outcome</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Haematology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">age</style></keyword><keyword><style  face="normal" font="default" size="100%">Elderly</style></keyword><keyword><style  face="normal" font="default" size="100%">International Staging System</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple myeloma</style></keyword><keyword><style  face="normal" font="default" size="100%">Prognostic factors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2005</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-26844556860&amp;doi=10.1111%2fj.1600-0609.2005.00532.x&amp;partnerID=40&amp;md5=8478e2ae5bc77e53d8175b58eadabbff</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">75</style></volume><pages><style face="normal" font="default" size="100%">370 - 375</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Objectives: Purpose of this study was to compare prognostic factors and outcome of patients with multiple myeloma (MM) aged &gt; 70 yr at diagnosis with those of younger patients. We also applied the recently proposed International Staging System (ISS) for MM in these patients. Patients and methods: Among 1,162 newly diagnosed, symptomatic MM patients included in our database, 357 (31%) were &gt; 70 yr of age. Clinical and laboratory variables were evaluated in patients &gt; 70 yr and in younger patients and were assessed for possible correlation with survival in patients &gt; 70 yr of age. Results: Most clinical and laboratory features were similar in the two groups of patients but older patients presented more frequently with advanced ISS (P = 0.02). Despite similar response rates to primary treatment, younger patients survived longer than patients &gt; 70 yr of age (40 vs. 28 months, P = 0.001). There was a longer survival of younger patients than that of older patients diagnosed with ISS stage 1 (median 71 vs. 54 months, P = 0.007) and ISS stage-2 patients (median: 38 vs. 26 months, P = 0.0008) but for patients with ISS stage 3 median survival was similarly poor in the younger and older age group (21 and 20 months, P = 0.283). Other variables associated with impaired prognosis were severe anemia, extensive bone marrow plasmacytosis and elevated serum LDH. Conclusions: Older patients with MM present more often with advanced ISS and have significantly shorter survival than younger patients. The ISS retained its prognostic significance within the group of elderly patients. © Blackwell Munksgaard 2005.</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><notes><style face="normal" font="default" size="100%">Cited By :34Export Date: 21 February 2017</style></notes></record></records></xml>