<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anagnostopoulos, A.</style></author><author><style face="normal" font="default" size="100%">Gika, D.</style></author><author><style face="normal" font="default" size="100%">Hamilos, G.</style></author><author><style face="normal" font="default" size="100%">Zervas, K.</style></author><author><style face="normal" font="default" size="100%">Zomas, A.</style></author><author><style face="normal" font="default" size="100%">Pouli, A.</style></author><author><style face="normal" font="default" size="100%">Zorzou, M.</style></author><author><style face="normal" font="default" size="100%">Kastritis, E.</style></author><author><style face="normal" font="default" size="100%">Anagnostopoulos, N.</style></author><author><style face="normal" font="default" size="100%">Tassidou, A.</style></author><author><style face="normal" font="default" size="100%">Anagnostou, D.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.-A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Treatment of relapsed/refractory multiple myeloma with thalidomide-based regimens: Identification of prognostic factors</style></title><secondary-title><style face="normal" font="default" size="100%">Leukemia and Lymphoma</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Advanced myeloma</style></keyword><keyword><style  face="normal" font="default" size="100%">International Staging System</style></keyword><keyword><style  face="normal" font="default" size="100%">Prognostic factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Staging</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2004</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-8644240941&amp;doi=10.1080%2f10428190410001733772&amp;partnerID=40&amp;md5=7d575dd2b82b3240c0516846c22aa961</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">45</style></volume><pages><style face="normal" font="default" size="100%">2275 - 2279</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">We evaluated the predictive value of several parameters, including the International Staging System (ISS) for myeloma, in patients with advanced disease treated with thalidomide-based regimens (TBR). We analyzed 119 patients, from 3 phase II studies. Patients with pretreatment β2 microglobulin &lt; 3.5 mg/l and albumin ≥ 3.5 g /dl were scored ISS stage 1, patients with β2 microglobulin &lt; 3.5 mg/1 and albumin &lt; 3.5 g/dl or β2 microglobulin 3.5-5.5 mg/l regardless of albumin levels were scored ISS stage 2, patients with β2 microglobulin &gt; 5.5 mg/l ISS stage 3. ISS stage was 1, 2 and 3 in 45, 32 and 23% of patients respectively. Seventy-four patients (62% achieved at least partial response. Median progression-free and overall survival were 8 months and 19.5 months respectively. ISS stage, serum LDH and performance status were independent predictive factors for survival. Based on these 3 variables a scoring system was developed with survival times of 38.1, 28.8 and 5.8 months for scores 0, 1 and 2 respectively. The ISS staging system was highly predictive for overall survival of patients with advanced myeloma treated with TBR. With the addition of performance status and serum LDH, a simple scoring system was developed which may help select patients likely to benefit from TBR. © 2004 Taylor &amp; Francis Ltd.</style></abstract><issue><style face="normal" font="default" size="100%">11</style></issue><notes><style face="normal" font="default" size="100%">Cited By :8Export Date: 21 February 2017</style></notes></record></records></xml>