<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sfikakis, P.P.</style></author><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Souliotis, V.L.</style></author><author><style face="normal" font="default" size="100%">Charalambopoulos, D.</style></author><author><style face="normal" font="default" size="100%">Mavrikakis, M.</style></author><author><style face="normal" font="default" size="100%">Panayiotidis, P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of 2-chlorodeoxyadenosine and gold sodium thiomalate on human bcl-2 gene expression</style></title><secondary-title><style face="normal" font="default" size="100%">Immunopharmacology and Immunotoxicology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2-chlorodeoxyadenosine</style></keyword><keyword><style  face="normal" font="default" size="100%">apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Bcl-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Gold salts</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin- 2</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymphocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1998</style></year><pub-dates><date><style  face="normal" font="default" size="100%">1998</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031919092&amp;partnerID=40&amp;md5=d366fe16003ab5b66294597fad6592a7</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">20</style></volume><pages><style face="normal" font="default" size="100%">63 - 77</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Aberrant expression of apoptosis-related genes including the 'cell death suppressor gene' bcl-2, may play an important pathogenetic role in cancer expression by 2-CdA, and or GST would provide a basis for their efficacy in suppressing arthritis by interfering with the upregulation of bcl-2 mRNA in the synovial lining cells (Muller-Laduer et al., 1995). However, the lack of a direct inhibitory effect on the induction of bcl-2 biosynthesis at the relatively high concentrations tested suggests that both GST and 2-CdA exert their beneficial effects in these patients through a bcl-2 independent mechanism.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><notes><style face="normal" font="default" size="100%">Cited By :2Export Date: 21 February 2017</style></notes></record></records></xml>