<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dimopoulos, M.A.</style></author><author><style face="normal" font="default" size="100%">Finn, L.</style></author><author><style face="normal" font="default" size="100%">Logothetis, C. J.</style></author><author><style face="normal" font="default" size="100%">Droller, M.J.</style></author><author><style face="normal" font="default" size="100%">Yagoda, A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pattern of failure and survival of patients with metastatic urothelial tumors relapsing after cisplatinum-based chemotherapy</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Urology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bladder neoplasms</style></keyword><keyword><style  face="normal" font="default" size="100%">Cisplatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Recurrence</style></keyword><keyword><style  face="normal" font="default" size="100%">Survival</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1994</style></year><pub-dates><date><style  face="normal" font="default" size="100%">1994</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028089224&amp;partnerID=40&amp;md5=abb445ae32e6e88184ac18b997d2e86b</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">151</style></volume><pages><style face="normal" font="default" size="100%">598 - 601</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Cis-platinum-based chemotherapy combinations have improved the outcome of patients with metastatic urothelial tumors, since two-thirds of these patients respond to treatment. Nevertheless, the majority of such patients have relapse within a median of 12 months. To define the pattern of failure and subsequent outcome, we retrospectively assessed 58 consecutive patients with relapse after prior response to cis-platinum-based combination chemotherapy. Of the patients who presented initially with local-regional metastases, 74% had relapse with involvement of a similar site, while only 26% of these patients had visceral metastases at relapse. The median survival after relapse was 9 months, and parameters associated with longer survival were local-regional relapse (10.7 months) and response to salvage chemotherapy (12.6 months). These data suggest that select patients with urothelial tumors and local-regional metastases may benefit from consolidation therapy with surgery or radiotherapy after maximum response to chemotherapy.</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><notes><style face="normal" font="default" size="100%">Cited By :45Export Date: 21 February 2017</style></notes></record></records></xml>