<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afratis, N. A.</style></author><author><style face="normal" font="default" size="100%">Nikitovic, D.</style></author><author><style face="normal" font="default" size="100%">Multhaupt, H. A.</style></author><author><style face="normal" font="default" size="100%">Theocharis, A. D.</style></author><author><style face="normal" font="default" size="100%">Couchman, J. R.</style></author><author><style face="normal" font="default" size="100%">Karamanos, N. K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Syndecans - key regulators of cell signaling and biological functions</style></title><secondary-title><style face="normal" font="default" size="100%">FEBS J</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*cell adhesion</style></keyword><keyword><style  face="normal" font="default" size="100%">*growth factor receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">*growth factors</style></keyword><keyword><style  face="normal" font="default" size="100%">*integrins</style></keyword><keyword><style  face="normal" font="default" size="100%">*migration</style></keyword><keyword><style  face="normal" font="default" size="100%">*Signal Transduction</style></keyword><keyword><style  face="normal" font="default" size="100%">*signaling</style></keyword><keyword><style  face="normal" font="default" size="100%">*syndecans</style></keyword><keyword><style  face="normal" font="default" size="100%">Actin Cytoskeleton/chemistry/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Calcium/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Adhesion</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Movement</style></keyword><keyword><style  face="normal" font="default" size="100%">Extracellular Matrix Proteins/genetics/*metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Extracellular Matrix/chemistry/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">homeostasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Integrins/genetics/*metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Neoplasms/genetics/*metabolism/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Domains</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Kinases/genetics/*metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptors, Growth Factor/genetics/*metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Syndecans/genetics/*metabolism</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">1</style></number><edition><style face="normal" font="default" size="100%">20161118</style></edition><volume><style face="normal" font="default" size="100%">284</style></volume><pages><style face="normal" font="default" size="100%">27-41</style></pages><isbn><style face="normal" font="default" size="100%">1742-4658 (Electronic)1742-464X (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Syndecans are a small family of four transmembrane proteoglycans in mammals. They have similar structural organization, consisting of an N-terminal ectodomain, single transmembrane domain and C-terminal cytoplasmic domain. Over the years, the association between syndecans and the actin cytoskeleton has been established, which has consequences for the regulation of cell adhesion and migration. Specifically, ecto- and cytoplasmic domains are responsible for the interaction with extracellular matrix molecules and intracellular kinases, respectively. These interactions indicate syndecans as key molecules during cancer initiation and progression. Particularly syndecans interact with other cell surface receptors, such as growth factor receptors and integrins, which lead to activation of downstream signaling pathways, which are critical for the cellular behavior. Moreover, this review describes the key role of syndecans in intracellular calcium regulation and homeostasis. The syndecan-mediated regulation of calcium metabolism is highly correlated with cells' adhesion phenotype through the actin cytoskeleton and formation of junctions, with implications during differentiation and disease progression.</style></abstract><accession-num><style face="normal" font="default" size="100%">27790852</style></accession-num><notes><style face="normal" font="default" size="100%">Afratis, Nikolaos ANikitovic, DraganaMulthaupt, Hinke A BTheocharis, Achilleas DCouchman, John RKaramanos, Nikos KengReviewResearch Support, Non-U.S. Gov'tEngland2016/10/30FEBS J. 2017 Jan;284(1):27-41. doi: 10.1111/febs.13940. Epub 2016 Nov 18.</style></notes><auth-address><style face="normal" font="default" size="100%">Biochemistry, Biochemical Analysis &amp; Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece.Biotech Research &amp; Innovation Center, University of Copenhagen, Denmark.Laboratory of Anatomy-Histology-Embryology, School of Medicine, University of Crete, Heraklion, Greece.</style></auth-address><remote-database-name><style face="normal" font="default" size="100%">Medline</style></remote-database-name><remote-database-provider><style face="normal" font="default" size="100%">NLM</style></remote-database-provider></record></records></xml>