@article {491,
	title = {Severe chronic allergic (and related) diseases: a uniform approach{\textendash}a MeDALL{\textendash}GA2LEN{\textendash}ARIA position paper},
	journal = {Int Arch Allergy Immunol},
	volume = {158},
	number = {3},
	year = {2012},
	pages = {216-31},
	type = {Journal Article},
	abstract = {Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.},
	keywords = {Asthma Chronic Disease Comorbidity Dermatitis, Atopic Humans Hypersensitivity Practice Guidelines as Topic Rhinitis Severity of Illness Index Sinusitis Urticaria},
	issn = {1423-0097},
	doi = {10.1159/000332924},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22382913},
	author = {Bousquet, J. and Anto, J. M. and Demoly, P. and Sch{\"u}nemann, H. J. and Togias, A. and Akdis, M. and Auffray, C. and Bachert, C. and Bieber, T. and Bousquet, P. J. and Carlsen, K. H. and Casale, T. B. and Cruz, A. A. and Keil, T. and Lodrup Carlsen, K. C. and Maurer, M. and Ohta, K. and Papadopoulos, N. G. and Roman Rodriguez, M. and Samolinski, B. and Agache, I. and Andrianarisoa, A. and Ang, C. S. and Annesi-Maesano, I. and Ballester, F. and Baena-Cagnani, C. E. and Basaga{\~n}a, X. and Bateman, E. D. and Bel, E. H. and Bedbrook, A. and Begh{\'e}, B. and Beji, M. and Ben Kheder, A. and Benet, M. and Bennoor, K. S. and Bergmann, K. C. and Berrissoul, F. and Bindslev Jensen, C. and Bleecker, E. R. and Bonini, S. and Boner, A. L. and Boulet, L. P. and Brightling, C. E. and Brozek, J. L. and Bush, A. and Busse, W. W. and Camargos, P. A. and Canonica, G. W. and Carr, W. and Cesario, A. and Chen, Y. Z. and Chiriac, A. M. and Costa, D. J. and Cox, L. and Custovic, A. and Dahl, R. and Darsow, U. and Didi, T. and Dolen, W. K. and Douagui, H. and Dubakiene, R. and El-Meziane, A. and Fonseca, J. A. and Fokkens, W. J. and Fthenou, E. and Gamkrelidze, A. and Garcia-Aymerich, J. and Gerth van Wijk, R. and Gimeno-Santos, E. and Guerra, S. and Haahtela, T. and Haddad, H. and Hellings, P. W. and Hellquist-Dahl, B. and Hohmann, C. and Howarth, P. and Hourihane, J. O. and Humbert, M. and Jacquemin, B. and Just, J. and Kalayci, O. and Kaliner, M. A. and Kauffmann, F. and Kerkhof, M. and Khayat, G. and Koffi N{\textquoteright}Goran, B. and Kogevinas, M. and Koppelman, G. H. and Kowalski, M. L. and Kull, I. and Kuna, P. and Larenas, D. and Lavi, I. and Le, L. T. and Lieberman, P. and Lipworth, B. and Mahboub, B. and Makela, M. J. and Martin, F. and Martinez, F. D. and others}
}
