@article {521,
	title = {Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children},
	journal = {J Asthma},
	volume = {41},
	number = {3},
	year = {2004},
	pages = {285-7},
	type = {Journal Article},
	abstract = {Recurrent viral infections are frequently observed in children with atopic asthma. In this study we investigated the ability of the synthetic immunomodulator pidotimod to affect in vitro the phenotype and/or cytokine profile of blood cells in relation to atopic asthma. Peripheral blood mononuclear cells were isolated from 13 atopic asthmatic and 9 normal children and stimulated in culture with mitogen either in the presence or not of the drug. Expression of surface markers was evaluated by flow cytometry, and production of interleukin-4 and interferon-gamma was measured in supernatants. Pidotimod was able to down-regulate the expression of CD30 on cells from both atopic and normal subjects. Because CD30 has been associated with Th-2 cells, this observation supports the possibility of pidotimod being able to affect the Th-1/Th-2 balance in atopic asthma.},
	keywords = {Antigens, CD30 Asthma Child Child, Helper-Inducer Thiazoles Thiazolidines, Mononuclear Male Pyrrolidonecarboxylic Acid T-Lymphocytes, Preschool Cytokines Down-Regulation Female Humans Hypersensitivity Immunologic Factors Leukocytes},
	issn = {0277-0903},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15260461},
	author = {Gourgiotis, D. and Papadopoulos, N. G. and Bossios, A. and Zamanis, P. and Saxoni-Papageorgiou, P.}
}
