@article {526,
	title = {Conception via in vitro fertilization and delivery by Caesarean section are associated with paediatric asthma incidence},
	journal = {Clin Exp Allergy},
	volume = {43},
	number = {9},
	year = {2013},
	pages = {1058-66},
	type = {Journal Article},
	abstract = {The association between perinatal factors and asthma inception is under rigorous investigation. Nevertheless, evidence of a correlation between asthma, conception via in vitro fertilization (IVF) and delivery through Caesarean section (C-section) is inconclusive.|We aimed to assess the relation of asthma incidence with IVF and C-section, after controlling for several potential confounding factors.|Parent-reported wheeze in the last 12 months (current), wheeze ever, physician-diagnosed asthma, method of conception, and type of delivery were recorded from questionnaires filled in by the parents of 2016 Greek children aged 9-13, (the Healthy Growth Study population). Some perinatal data were recorded from children{\textquoteright}s medical records and others were reported by parents; anthropometric measurements were also conducted in children.|IVF was correlated with physician-diagnosed asthma (OR = 2.25; 95\% CI = 1.11-4.56), but not with current/ever wheeze after adjustment for potential confounding factors. After adjustment, C-section was also associated with asthma (OR = 1.39; 95\% CI = 1.04-1.87), but not with current/ever wheeze. When the association of both IVF and C-section with asthma was examined in the same multivariate logistic regression model, it was weakened to borderline significance (OR = 2.04; 95\% CI = 1-4.15 and OR = 1.34; 95\% CI = 1-1.81 respectively).|Conception via IVF and delivery by C-section may predispose children to future asthma development. Either variable could also exert a confounding effect on the link of the other to asthma; this may partially be accountable for inconsistencies in the findings of pertinent studies.},
	issn = {1365-2222},
	doi = {10.1111/cea.12152},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23957341},
	author = {Guibas, G. V. and Moschonis, G. and Xepapadaki, P. and Roumpedaki, E. and Androutsos, O. and Manios, Y. and Papadopoulos, N. G.}
}
