@article {601,
	title = {Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis},
	journal = {Ann Allergy Asthma Immunol},
	volume = {96},
	number = {5},
	year = {2006},
	pages = {673-8},
	type = {Journal Article},
	abstract = {The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis.|To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR).|Sixty-one patients were recruited from 3 referral allergy centers. Inclusion criteria were history of SAR for 2 years or longer, sensitization to relevant local pollen (grasses, Parietaria, and olive), and age older than 12 years.|An open-label, randomized, parallel-group, "real-life" study design was used. Patients received mometasone furoate nasal spray once daily or nedocromil sodium nasal spray 3 times daily starting 2 to 4 weeks before the pollen season and continuing for up to 4 months. Instructions regarding the use of additional medications were given. Diary cards recording symptoms, use of medication, and adverse events were kept by the patients.|All 61 patients completed the study. The prophylactic use of mometasone furoate vs nedocromil sodium led to significantly more days without symptoms (75.1\% vs 54.5\%; P < .001). The mometasone furoate group also had lower nasal symptom scores (mean, 1.4 vs 2.9; median, 0 vs 2; P < .001) and was more satisfied (93.1\% vs 43.5\%; P < .001). No serious adverse event was recorded, and there was no difference between the treatments in any adverse event.|Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium.},
	keywords = {Administration, Allergic, Intranasal Adolescent Adult Anti-Allergic Agents Child Drug Administration Schedule Female Humans Male Middle Aged Nedocromil Pregnadienediols Rhinitis, Seasonal},
	issn = {1081-1206},
	doi = {10.1016/S1081-1206(10)61064-2},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/16729779},
	author = {Pitsios, C. and Papadopoulos, D. and Kompoti, E. and Manoussakis, E. and Garris, V. and Petalas, K. and Tassios, I. and Baibas, N. and Kontou-Fili, K. and Saxoni-Papageorgiou, P. and Papadopoulos, N. G.}
}
