@article {635,
	title = {Synergistic effects of fluticasone propionate and salmeterol on inhibiting rhinovirus-induced epithelial production of remodelling-associated growth factors},
	journal = {Clin Exp Allergy},
	volume = {36},
	number = {10},
	year = {2006},
	pages = {1268-73},
	type = {Journal Article},
	abstract = {Rhinoviruses (RV), the major trigger of acute asthma exacerbations, are able to infect bronchial epithelium and induce production of pro-inflammatory, but also angiogenic and pro-fibrotic mediators. Fluticasone propionate (FP) and salmeterol (S) are clinically effective and act synergistically in controlling persistent asthma; however, their effect on virus-associated asthma is less clear.|The aim of this study was to assess the individual and combined effects of FP and S on RV-induced epithelial production of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2).|Bronchial epithelial cells (BEAS-2B) were exposed in vitro to RV and were subsequently treated with FP and S, at physiologically relevant concentrations, alone or in combination. VEGF and FGF-2 were measured in the supernatants of these cultures using ELISA.|FP was able to reduce RV-induced VEGF production in a dose-dependent manner. S also induced a smaller reduction; addition of both factors inhibited VEGF synergistically. FGF-2 production was not inhibited by either FP or S alone, but was significantly reduced when both substances were present in the culture.|This study demonstrates that FP and S may synergistically inhibit the production of angiogenic and/or pro-fibrotic factors that are induced after RV infection of BEAS-2B and are implicated in airway remodelling, suggesting that this combination may represent an important therapeutic option on virus-induced asthma.},
	keywords = {Albuterol Androstadienes Anti-Inflammatory Agents Bronchi Cell Line Dose-Response Relationship, Drug Drug Synergism Enzyme-Linked Immunosorbent Assay Epithelial Cells Fibroblast Growth Factor 2 HeLa Cells Humans Intercellular Signaling Peptides and Proteins Picornaviridae Infections Rhinovirus Vascular Endothelial Growth Factor A},
	issn = {0954-7894},
	doi = {10.1111/j.1365-2222.2006.02566.x},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/17014435},
	author = {Volonaki, E. and Psarras, S. and Xepapadaki, P. and Psomali, D. and Gourgiotis, D. and Papadopoulos, N. G.}
}
