@article {639,
	title = {Modulation of the epithelial inflammatory response to rhinovirus in an atopic environment},
	journal = {Clin Exp Allergy},
	volume = {38},
	number = {3},
	year = {2008},
	pages = {466-72},
	type = {Journal Article},
	abstract = {Immune responses to rhinovirus (RV) as well as direct effects of RV on respiratory epithelium may contribute to the induction of asthma exacerbations.|To evaluate the effect of the environment resulting from an atopic immune response on RV-induced epithelial inflammation, replication and cytotoxicity.|Peripheral blood mononuclear cells (PBMC) from atopic asthmatic subjects and matched controls (12 pairs) were isolated and stimulated by RVs. Human bronchial epithelial (BEAS-2B) cells were infected with RV in the presence of conditioned media from RV-stimulated PBMC cultures. IL-6, IL-8, RANTES and TGF-beta1 levels were measured by ELISA, RV-induced cytotoxicity by a colorimetric method and RV titres on Ohio-HeLa cells.|RV-induced epithelial production of IL-6, IL-8 and RANTES was significantly lower, while TGF-beta1 was higher when cells were exposed to conditioned media from atopic asthmatic subjects compared with those from normal controls. Exposure to the {\textquoteright}atopic{\textquoteright} environment also resulted in elevated RV titres and increased RV-induced cytotoxicity.|Under the influence of an atopic environment, the epithelial inflammatory response to RV is down-regulated, associated with increased viral proliferation and augmented cell damage, while TGF is up-regulated. These changes may help explain the propensity of atopic asthmatic individuals to develop lower airway symptoms after respiratory infections and indicate a mechanism through which viral infections may promote airway remodelling.},
	keywords = {Adult Antibody Formation Asthma Bronchi Bronchitis Cell Death Cells, Conditioned Cytokines Epithelial Cells Female Humans Hypersensitivity, Cultured Culture Media, Immediate Inflammation Mediators Interferon-gamma Male Monocytes Picornaviridae Infections Rhinovirus Transforming Growth Factor beta1 Up-Regulation Virus Replication},
	issn = {1365-2222},
	doi = {10.1111/j.1365-2222.2007.02906.x},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/18269670},
	author = {Xatzipsalti, M. and Psarros, F. and Konstantinou, G. and Gaga, M. and Gourgiotis, D. and Saxoni-Papageorgiou, P. and Papadopoulos, N. G.}
}
