<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bousquet, J.</style></author><author><style face="normal" font="default" size="100%">Schünemann, H. J.</style></author><author><style face="normal" font="default" size="100%">Bousquet, P. J.</style></author><author><style face="normal" font="default" size="100%">Bachert, C.</style></author><author><style face="normal" font="default" size="100%">Canonica, G. W.</style></author><author><style face="normal" font="default" size="100%">Casale, T. B.</style></author><author><style face="normal" font="default" size="100%">Demoly, P.</style></author><author><style face="normal" font="default" size="100%">Durham, S.</style></author><author><style face="normal" font="default" size="100%">Carlsen, K. H.</style></author><author><style face="normal" font="default" size="100%">Malling, H. J.</style></author><author><style face="normal" font="default" size="100%">Passalacqua, G.</style></author><author><style face="normal" font="default" size="100%">Simons, F. E.</style></author><author><style face="normal" font="default" size="100%">Anto, J.</style></author><author><style face="normal" font="default" size="100%">Baena-Cagnani, C. E.</style></author><author><style face="normal" font="default" size="100%">Bergmann, K. C.</style></author><author><style face="normal" font="default" size="100%">Bieber, T.</style></author><author><style face="normal" font="default" size="100%">Briggs, A. H.</style></author><author><style face="normal" font="default" size="100%">Brozek, J.</style></author><author><style face="normal" font="default" size="100%">Calderon, M. A.</style></author><author><style face="normal" font="default" size="100%">Dahl, R.</style></author><author><style face="normal" font="default" size="100%">Devillier, P.</style></author><author><style face="normal" font="default" size="100%">Gerth van Wijk, R.</style></author><author><style face="normal" font="default" size="100%">Howarth, P.</style></author><author><style face="normal" font="default" size="100%">Larenas, D.</style></author><author><style face="normal" font="default" size="100%">Papadopoulos, N. G.</style></author><author><style face="normal" font="default" size="100%">Schmid-Grendelmeier, P.</style></author><author><style face="normal" font="default" size="100%">Zuberbier, T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">How to design and evaluate randomized controlled trials in immunotherapy for allergic rhinitis: an ARIA-GA(2) LEN statement</style></title><secondary-title><style face="normal" font="default" size="100%">Allergy</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Administration</style></keyword><keyword><style  face="normal" font="default" size="100%">Allergic</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunologic Humans Injections</style></keyword><keyword><style  face="normal" font="default" size="100%">Perennial Rhinitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Preschool Desensitization</style></keyword><keyword><style  face="normal" font="default" size="100%">Seasonal Severity of Illness Index Treatment Outcome</style></keyword><keyword><style  face="normal" font="default" size="100%">Subcutaneous Mites Pollen Quality of Life Randomized Controlled Trials as Topic Rhinitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sublingual Adolescent Adult Allergens Animals Child Child</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/21496059</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">6</style></number><volume><style face="normal" font="default" size="100%">66</style></volume><pages><style face="normal" font="default" size="100%">765-74</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Specific immunotherapy (SIT) is one of the treatments for allergic rhinitis. However, for allergists, nonspecialists, regulators, payers, and patients, there remain gaps in understanding the evaluation of randomized controlled trials (RCTs). Although treating the same diseases, RCTs in SIT and pharmacotherapy should be considered separately for several reasons, as developed in this study. These include the severity and persistence of allergic rhinitis in the patients enrolled in the study, the problem of the placebo, allergen exposure (in particular pollen and mite), the analysis and reporting of the study, the level of symptoms of placebo-treated patients, the clinical relevance of the efficacy of SIT, the need for a validated combined symptom-medication score, the differences between children and adults and pharmacoeconomic analyses. This statement reviews issues raised by the interpretation of RCTs in sublingual immunotherapy. It is not possible to directly extrapolate the rules or parameters used in medication RCTs to SIT. It also provides some suggestions for the research that will be needed. Interestingly, some of the research questions can be approached with the available data obtained from large RCTs.</style></abstract><work-type><style face="normal" font="default" size="100%">Journal Article</style></work-type></record></records></xml>