@article {38965,
	title = {Acetyl Cholinesterase Inhibitors and Cell-Derived Peripheral Inflammatory Cytokines in Early Stages of Alzheimer{\textquoteright}s Disease},
	journal = {J Clin Psychopharmacol},
	volume = {38},
	number = {2},
	year = {2018},
	note = {\&nbsp;10.1097/JCP.0000000000000840},
	month = {Apr},
	pages = {138-143},
	abstract = {BACKGROUND: Clinical and preclinical studies firmly support the involvement of the inflammation in the pathogenesis of Alzheimer{\textquoteright}s disease (AD). Despite acetylcholinesterase inhibitors (AChEI) being widely used in AD patients, there is no conclusive evidence about their impact on the inflammatory response. METHODS: This study investigates peripheral proinflammatory cytokines (interferon gamma [IFN-γ], tumor necrosis factor alpha [TNF-α], and interleukins 1β [IL-1β] and 6 [IL-6]) by firstly comparing peripheral blood mononuclear cell (PBMC)-derived secretion in drug-na{\"\i}ve and AChEI-treated AD patients versus healthy controls. A subset of those drug-na{\"\i}ve AD patients, who were prescribed the AChEI donepezil, was followed-up for 6 months to investigate if donepezil suppresses proinflammatory cell-derived cytokine secretion. RESULTS: Patients with AD showed higher levels of PBMC-derived proinflammatory cytokines (IFN-γ, TNF-α, IL-1β, and IL-6) in comparison with healthy controls. On reexamination, previously drug-na{\"\i}ve AD patients who received donepezil treatment for 6 months displayed a decrease in cell-derived IFN-γ, TNF-α, IL-1β, and IL-6. CONCLUSIONS: Proinflammatory PBMC-derived cytokines were increased in patients with AD in comparison with healthy controls and donepezil-reduced proinflammatory cytokines when examining drug-na{\"\i}ve AD patients before and after AChEI treatment.},
	keywords = {Aged, Alzheimer Disease/*blood/*drug therapy, Cholinesterase Inhibitors/administration \& dosage/*pharmacology, Cytokines/*blood/*drug effects, Donepezil, Female, Follow-Up Studies, Humans, Indans/administration \& dosage/*pharmacology, Inflammation/*blood/*drug therapy, Male, Middle Aged, Piperidines/administration \& dosage/*pharmacology},
	isbn = {0271-0749},
	author = {Kokras, N and Stamouli, E. and Sotiropoulos, I and Katirtzoglou, E. A. and Siarkos, K. T. and Dalagiorgou, G. and Alexandraki, K.I. and Coulocheri, S. and Piperi, C. and Politis, A. M.}
}
