<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eck, S. R.</style></author><author><style face="normal" font="default" size="100%">Kokras, N</style></author><author><style face="normal" font="default" size="100%">Wicks, B.</style></author><author><style face="normal" font="default" size="100%">Baltimas, P.</style></author><author><style face="normal" font="default" size="100%">Hall, A.</style></author><author><style face="normal" font="default" size="100%">van Bendegem, N.</style></author><author><style face="normal" font="default" size="100%">Salvatore, M.</style></author><author><style face="normal" font="default" size="100%">Cohen, S. R.</style></author><author><style face="normal" font="default" size="100%">Bergmann, J.</style></author><author><style face="normal" font="default" size="100%">Ceretti, A.</style></author><author><style face="normal" font="default" size="100%">Parikh, V.</style></author><author><style face="normal" font="default" size="100%">Dalla, C</style></author><author><style face="normal" font="default" size="100%">Bangasser, D. A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Corticotropin releasing factor in the nucleus basalis of Meynert impairs attentional performance and reduces levels of glutamate and taurine in male and female rats</style></title><secondary-title><style face="normal" font="default" size="100%">Neuropharmacology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Basal Nucleus of Meynert</style></keyword><keyword><style  face="normal" font="default" size="100%">*Corticotropin-Releasing Hormone/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Attention</style></keyword><keyword><style  face="normal" font="default" size="100%">Basal forebrain</style></keyword><keyword><style  face="normal" font="default" size="100%">Cognition</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">gamma-Aminobutyric Acid/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutamate</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutamic Acid/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Taurine/metabolism</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Dec 15</style></date></pub-dates></dates><edition><style face="normal" font="default" size="100%">20221008</style></edition><volume><style face="normal" font="default" size="100%">221</style></volume><pages><style face="normal" font="default" size="100%">109280</style></pages><isbn><style face="normal" font="default" size="100%">0028-3908 (Print)0028-3908</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Psychiatric disorders that are characterized by impairments in sustained attention, including attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), and major depression are also sensitive to exacerbation by stress. Sustained attention relies on cholinergic and non-cholinergic projections from the nucleus basalis of Meynert (NBM) in the basal forebrain to the medial prefrontal cortex (mPFC). We have previously shown that central administration of the stress neuropeptide corticotropin releasing factor (CRF) impairs performance on the sustained attention task (SAT) in adult male and female rats. The present study investigated whether this effect was mediated by CRF's action in the NBM. Rats were administered CRF in the NBM and subsequent SAT performance was measured. A high dose of CRF (100&amp;nbsp;ng) significantly impaired performance on non-signaled events across sex. Because performance on non-signaled events is believed to depend on non-cholinergic (i.e., GABA and glutamate) signaling, high performance liquid chromatography was used to quantify amino acid levels in the NBM and mPFC. We found females have higher levels of glutamate, glutamine, GABA glycine, and alanine in the NBM than males. Importantly, CRF in the NBM led to a local decrease of taurine and several amino acids involved in glutamate synthesis in males and females, changes which may mediate the CRF-induced SAT performance deficit. Together these studies suggest that CRF regulation of amino acids in the NMB contributes to stress-induced attention deficits.</style></abstract><accession-num><style face="normal" font="default" size="100%">36216029</style></accession-num><notes><style face="normal" font="default" size="100%">10.1016/j.neuropharm.2022.109280</style></notes><custom2><style face="normal" font="default" size="100%">PMC9883789</style></custom2><custom6><style face="normal" font="default" size="100%">NIHMS1859396</style></custom6><auth-address><style face="normal" font="default" size="100%">Department of Psychology and Neuroscience, Temple University, Philadelphia, PA 19122, USA.Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527, Goudi, Athens, Greece; First Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Greece.Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 11527, Goudi, Athens, Greece.Department of Psychology and Neuroscience, Temple University, Philadelphia, PA 19122, USA; Neuroscience Institute, Georgia State University, Atlanta, GA 30303, USA. Electronic address: dbangasser@gsu.edu.</style></auth-address><remote-database-provider><style face="normal" font="default" size="100%">NLM</style></remote-database-provider></record></records></xml>