Pantazis N, Porter K, Costagliola D, de Luca A, Ghosn J, Guiguet M, Johnson AM, Kelleher AD, Morrison C, Thiebaut R, et al. Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study. The Lancet HIV. 2014;1:e119–e126.