@article {36580,
	title = {Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc(1)},
	journal = {Nat Struct Mol Biol},
	volume = {26},
	number = {1},
	year = {2019},
	note = {Hartley, Andrew MLukoyanova, NatalyaZhang, YunyiCabrera-Orefice, AlfredoArnold, SusanneMeunier, BrigittePinotsis, NikosMarechal, AmandineengWellcome Trust/United KingdomMR/M00936X/1/MRC_/Medical Research Council/United KingdomResearch Support, Non-U.S. Gov{\textquoteright}tNat Struct Mol Biol. 2019 Jan;26(1):78-83. doi: 10.1038/s41594-018-0172-z. Epub 2018 Dec 31.},
	month = {Jan},
	pages = {78-83},
	edition = {2019/01/02},
	abstract = {Cytochrome c oxidase (complex IV, CIV) is known in mammals to exist independently or in association with other respiratory proteins to form supercomplexes (SCs). In Saccharomyces cerevisiae, CIV is found solely in an SC with cytochrome bc(1) (complex III, CIII). Here, we present the cryogenic electron microscopy (cryo-EM) structure of S. cerevisiae CIV in a III(2)IV(2) SC at 3.3 A resolution. While overall similarity to mammalian homologs is high, we found notable differences in the supernumerary subunits Cox26 and Cox13; the latter exhibits a unique arrangement that precludes CIV dimerization as seen in bovine. A conformational shift in the matrix domain of Cox5A-involved in allosteric inhibition by ATP-may arise from its association with CIII. The CIII-CIV arrangement highlights a conserved interaction interface of CIII, albeit one occupied by complex I in mammalian respirasomes. We discuss our findings in the context of the potential impact of SC formation on CIV regulation.},
	keywords = {Electron Transport Complex III/genetics/*metabolism, Electron Transport Complex IV/genetics/metabolism, Membrane Proteins/genetics/metabolism, Microscopy, Electron, Mitochondrial Membranes, Mitochondrial Proteins/genetics/metabolism, Saccharomyces cerevisiae Proteins/genetics/*metabolism, Saccharomyces cerevisiae/genetics/*metabolism/ultrastructure},
	isbn = {1545-9985 (Electronic)1545-9993 (Print)1545-9985 (Linking)},
	author = {Hartley, A. M. and Lukoyanova, N. and Zhang, Y. and Cabrera-Orefice, A. and Arnold, S. and Meunier, B. and Pinotsis, N. and Marechal, A.}
}
