@article {36608,
	title = {Evasion of cGAS and TRIM5 defines pandemic HIV},
	journal = {Nat Microbiol},
	volume = {7},
	number = {11},
	year = {2022},
	note = {Zuliani-Alvarez, LorenaGovasli, Morten LRasaiyaah, JaneMonit, ChrisPerry, Stephen OSumner, Rebecca PMcAlpine-Scott, SimonDickson, ClaireRifat Faysal, K MHilditch, LauraMiles, Richard JBibollet-Ruche, FredericHahn, Beatrice HBoecking, TillPinotsis, NikosJames, Leo CJacques, David ATowers, Greg Jeng214344/WT_/Wellcome Trust/United KingdomMC_U105181010/MRC_/Medical Research Council/United KingdomDH_/Department of Health/United KingdomMR/S023380/1/MRC_/Medical Research Council/United Kingdom220863/WT_/Wellcome Trust/United KingdomU105181010/MRC_/Medical Research Council/United Kingdom200594/Z/16/Z/WT_/Wellcome Trust/United Kingdom108183/WT_/Wellcome Trust/United KingdomResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov{\textquoteright}tEnglandNat Microbiol. 2022 Nov;7(11):1762-1776. doi: 10.1038/s41564-022-01247-0. Epub 2022 Oct 26.},
	month = {Nov},
	pages = {1762-1776},
	edition = {2022/10/28},
	abstract = {Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans, only one, leading to human immunodeficiency virus (HIV) type 1(M) has become pandemic, causing over 80 million human infections. To understand the specific features associated with pandemic human-to-human HIV spread, we compared replication of HIV-1(M) with non-pandemic HIV-(O) and HIV-2 strains in myeloid cell models. We found that non-pandemic HIV lineages replicate less well than HIV-1(M) owing to activation of cGAS and TRIM5-mediated antiviral responses. We applied phylogenetic and X-ray crystallography structural analyses to identify differences between pandemic and non-pandemic HIV capsids. We found that genetic reversal of two specific amino acid adaptations in HIV-1(M) enables activation of TRIM5, cGAS and innate immune responses. We propose a model in which the parental lineage of pandemic HIV-1(M) evolved a capsid that prevents cGAS and TRIM5 triggering, thereby allowing silent replication in myeloid cells. We hypothesize that this capsid adaptation promotes human-to-human spread through avoidance of innate immune response activation.},
	keywords = {*HIV Infections/epidemiology/metabolism, *HIV-1/genetics, *Simian Immunodeficiency Virus/metabolism, Animals, Capsid/metabolism, Humans, Nucleotidyltransferases/genetics/metabolism, Phylogeny, Tripartite Motif Proteins/genetics/metabolism, Ubiquitin-Protein Ligases/genetics/metabolism},
	isbn = {2058-5276 (Electronic)2058-5276 (Linking)},
	author = {Zuliani-Alvarez, L. and Govasli, M. L. and Rasaiyaah, J. and Monit, C. and Perry, S. O. and Sumner, R. P. and McAlpine-Scott, S. and Dickson, C. and Rifat Faysal, K. M. and Hilditch, L. and Miles, R. J. and Bibollet-Ruche, F. and Hahn, B. H. and Boecking, T. and Pinotsis, N. and James, L. C. and Jacques, D. A. and Towers, G. J.}
}
