@article {174,
	title = {Alpha-1 antichymotrypsin gene signal peptide a/t polymorphism and primary intracerebral hemorrhage.},
	journal = {Eur Neurol},
	volume = {59},
	year = {2008},
	month = {2008},
	pages = {307-14},
	abstract = {BACKGROUND/AIMS: Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology. The TT genotype of the ACT signal peptide A/T polymorphism has been reported to confer susceptibility to primary intracerebral hemorrhage (PICH). We conducted a prospective study to test possible association of ACT signal peptide A/T polymorphism with PICH in a Greek cohort with enough power (80\%) to detect a twofold increase in the odds ratio.

METHODS: We prospectively recruited 147 patients with PICH. ACT signal peptide A/T genotypes were determined in patients and 206 healthy, age- and sex-matched control subjects from the neurology outpatient clinic using the polymerase chain reaction restriction fragment length polymorphism method.

RESULTS: Our study did not show an association between ACT signal peptide A/T polymorphism and PICH. We also failed to find any influence on age at onset, the location and volume of PICH as well as on clinical severity at admission or 6-month outcome.

CONCLUSION: Our data failed to confirm an association between ACT signal peptide A/T polymorphism and PICH. However, we cannot exclude the possibility that the TT genotype confers susceptibility at less than a twofold increase.},
	keywords = {Age of Onset, alpha 1-Antichymotrypsin, Case-Control Studies, Cerebral Hemorrhage, Comorbidity, Diabetes Mellitus, Female, Genetic Predisposition to Disease, Genotype, Humans, Hypercholesterolemia, Hypertension, Male, Middle Aged, Myocardial Ischemia, Polymorphism, Genetic, Smoking, Survival Analysis},
	issn = {1421-9913},
	doi = {10.1159/000121420},
	author = {Dardiotis, E and Hadjigeorgiou, G M and Dardioti, M and Scarmeas, N. and Paterakis, K and Aggelakis, K and Komnos, A and Tasiou, A and Xiromerisiou, G and Gabranis, I and Zintzaras, E and Papadimitriou, A and Karantanas, A}
}
